Best Supplements for Entrepreneurs

What Are The Best Supplements for Entrepreneurs?

Are There Supplements for Entrepreneurs?

Entrepreneurs are required to work harder. They work longer hours. In most cases, they have to be more efficient to succeed. It requires grit, persistence, investments, and tenacity. Fortunately, the entrepreneur can gain a bit of an edge by using the right daily supplements. Most of the supplements that are commonly found in an entrepreneur’s stack are considered “nootropics” (Denton, 2017). Most nootropics are natural herbs that provide a positive benefit to the mind or body, with very few negative side effects (Giurgea, 1983) (Gouliaev and Senning, 1994). There are, however, many synthetic drugs and supplements have also been accepted as nootropics (such as the racetams), so long as they enhance mental function or intellectual acuity.

Can Nootropics Be Used Together?

What Nootropics Are Found in Entrepreneur Stacks

Nootropic supplements are very commonly used in various combinations to produce enhanced effects (Blokland and Sambeth, 2016). Some combinations may not be desirable due to cross-tolerance or adverse reactions from taking them at the same time, however, there are many stacks which are effective (Suliman, et al., 2016). There are also many pre-made proprietary formulae which are well-known to work (Angel, 2018). Depending upon the desired effects, it is possible to achieve a variety of benefits from combining some of the best nootropics in the same stack.

What is a Nootropics Stack?

Nootropic stacks, or proprietary formulae as they are called in the commercial industry, are groups of nootropics taken as a daily regimen. Some entrepreneurs create their own stacks, while others prefer to purchase premade proprietary blends which are formulated to produce very specific effects.

Nootropics that Boost the Entrepreneurial Edge

There are many supplements which benefit entrepreneurs. These are some of the most preferred (and most effective) nootropics chosen by top entrepreneurs (in alphabetical order).

*Highlighted nootropics are ingredients in one or more Pirate Botanicals products.

5-HTP (5-hydroxytryptophan) Ingredient Found in Pirate Chill

5-HTP crosses the blood-brain barrier freely and is directly converted into serotonin. It is not limited by biochemical feedback inhibition and is a natural source of amino acids (Hinz, et al., 2012). As a clinically-effective serotonin precursor, it is a well-absorbed, orally-dosed substance with about 70 percent carrying into the bloodstream (Birdsall, 1998). One study notoriously proved that 5-HTP is able to positively influence the brain to improve mood and ultimately efficiency (Shaw, et al., 2002). Another more recent study explained that 5-HTP can positively change “fundamental cognitive operations such as attention” (Weinburg, 2018).

Acetyl L-Carnitine

Acetyl L-Carnitine has been proven to provide neuroprotective benefits to cells, as well as offering antioxidant properties to the body (Wang, et al, 2020)(Karalija, et al., 2012). It is easily absorbed in the stomach, making it an excellent addition to many supplements and is known to reduce fatigue (Swanson, 2018).

Ashwagandha (Withania somnifera)

Ashwagandha has been traditionally used in a variety of cultures for thousands of years. It has a heavy history of use in Ayurvedic medicine. It is a rather popular supplement used by entrepreneurs for its stress-relieving properties. Although many studies involve subjects which are already experiencing stress, these are arguably the best participants for the research. These studies do typically reveal a profound anxiolytic effect on subjects, and suggest that the herb moderates the hypothalamus-pituitary-adrenal axis (Lopresti, et al., 2019). It is also known as Indian Ginseng.

Bacopa Monnieri

Bacopa monnieri is native to many parts of the world and also goes by the common name Indian Pennywort. Although Bacopa is a bit weaker in terms of cognitive influence, it has been proven to have a slight effect on memory (Pase, et al., 2012). Specifically, it helps slightly improve memory recall, though the other cognitive domains have been understudied (2012).

Citicoline

Citicoline is commonly among individuals whom have suffered cognitive impairment (dementia, stroke, Alzheimer’s, etc.) to improve memory loss. Entrepreneurs sometimes include citicoline in their nootropic stack for a small boost to mental energy and learning. Truthfully, however, the studies to support the benefits of citicoline in healthy brains are lacking.

Coluracetam

Coluracetam is a member of the racetam family, and it is frequently used to treat Alzheimer’s disease. Although it is typically only used from a reparative/therapeutic perspective in terms of cognition and memory aid, more recent studies are suggesting it may boost cognition for a health brain as well (Malykh and Sadaie, 2010).

GABA (Gamma-Aminobutyric acid)

GABA plays an important role as a neurotransmitter in the central nervous system and reduces neuronal excitability (Olsen, 2006). Sometimes it is used in stress relief and relaxation formulae. It works by binding with GABA receptors and invoking a calming effect in the brain (Westphalen, 2019).

Ginkgo Biloba

Also known as the Maidenhair tree, is only native to China. It is one of the oldest species of plants used as a nootropic, dating back hundreds of millions of years old (Sun, 1998)! It is a very commonly used nutraceuticals offering neuroprotective properties, stress relief, and mild memory enhancement (Mahadevan, 2008).

Ginseng, Siberian (Eleutherococcus senticosus) Ingredient Found in Piratall

Ginseng is one of the most popular nootropics in entrepreneur supplements for its many offerings in terms of cognitive enhancement. Siberian Ginseng is often considered one of the best variants. It is an herbal adaptogen and antioxidant, helping the mind destress and feel clean (Abbai, 2016). It is believed to provide energy, combat fatigue, improve cognitive function, and improve stress response (Cohen, 2019).

Gotu Kola (Centella asiatica)

Gotu Kola is also known as Indian Pennywort. It grows in Asia and has been long revered for its medicinal and culinary uses. Gotu Kola is used in some entrepreneur stacks for its ability to improve blood flow and circulation (Gohil, et al., 2010).

Green Tea Extract Ingredient Found in Piratall

Green Tea extract is a very common constituent in an entrepreneur’s nootropic stack for its many cognitive benefits. It is a powerful adaptogen that is much more effective than most other nootropics at reducing stress (Keiko, 2017). Still, Green Tea extract is able to provide stimulation as it literally contains natural caffeine. The natural caffeine is distributed to the mind and body more evenly than most other caffeine sources. This provides the mind a greater boost to concentration and focus (Godsey, et al., 2020).

Guarana (Paullinia cupana)

Guarana has been hailed among entrepreneurs one of the most effective ingredients in energy drinks and supplements. In recent years, it has been used as a caffeine substitute and antioxidant (Peixoto, 2017). Mostly, it is included in entrepreneur stacks for its light stimulating effects (although it is still no where near as strong as actual caffeine).

Hawthorn (Crataegus) Ingredient Found in Piratall

Hawthorn is a bushy shrub that grows in temperate regions and yields bright red berries. It is well known in traditional Chinese medicine. Hawthorn is a powerful antioxidant and helps reduce stress levels (Strugala, et al., 2016). Both of these prime assets help entrepreneurs better function throughout their busy careers.

Huperzine A Ingredient Found in Piratall

Huperzine A is an alkaloid compound that is extracted from the Chinese firmoss Huperzia serrata. It is also a big part of traditional Chinese medicine. It has a tremendous history fighting cognitive impairments, Alzheimer’s, and is considered an anti-dementia aid (Yue, et al., 2012). Huperzine A is one of the most popular nootropics in entrepreneur stacks for its favorable impact to cognitive function (Wessinger, 2018).

L-Theanine Ingredient Found in Pirate Chill

L-Theanine is an amino acid analogue and is a special constituent isolated from gyokuro leaves. It is capable of enhancing mental sharpness in the same way as meditation (Challem, 2007). It is frequently used to promote peace and calmness (2007). It is found in many entrepreneur stacks for its stress relieving properties and ability to promote focus.

Lemon Balm (Melissa officinalis)

Lemon Balm is sometimes used in entrepreneur nootropic stacks to reduce stress and induce sleep (Cronkleton, 2019). In fact, it has even been proven to be effective when it is contained in food (Scholey, et al., 2014).

Lion’s Mane Mushroom (Hericium erinaceus)

Lion’s Mane Mushroom goes by many names including “Monkey Head Mushroom,” “Bearded Tooth Mushroom,” and even the “Hedgehog Mushroom.” It is found growing on American Beech trees in the late summer to early fall. Frequently, it is found in nootropic stacks for its mild cognitive improvement and mood regulation benefits (Wiley, 2019).

Modafinil (Provigil and Nuvigil)

Many brand names for Modafinil exist, probably most famous of the bunch being “Provigil.” It is frequently hailed as a cognitive enhancer, but very little research suggests any efficacy in terms of cognitive improvement. It is still used to help treat sleepiness and is listed as a scheduled substance in the United States.

Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester)

Although Noopept is not FDA approved, it is sometimes used by entrepreneurs for its purported neuroprotective and neuroregenerative properties. Truthfully, however, it has mostly only been studied in efficacy among people with traumatic brain injuries (Zainullina, 2019).

Passion Flower (Passiflora) Ingredient Found in Pirate Chill

Passion Flower (sometimes spelled Passionflower) are beautiful purple flowers which grow on vines that may come in the form of trees or shrubs. It has been used in traditional medicines for generations. Typically it is used for its sedative properties, for mild pain relief, and to reduce anxiety (NCCIH, 2016). It is a very common nootropic for entrepreneurs who need to relieve tension.

Phenibut

Phenibut is commonly used to reduce anxiety and improve sleep. Tolerance to phenibut builds rather quickly. And although it is an effective nootropics, side effects can be a little exhaustive, making it a less common choice for an entrepreneur stack (Lapin, 2001).

Piracetam

Although Piracetam is most commonly used to treat CNS disorders, it is found in a variety of nootropic stacks. Recent studies have revealed Piracetam is a somewhat promising candidate for being a neuroprotective and neuroregenerative nootropic (Malykh, 2010).

Rhodiola rosea Ingredient Found in Pirate Blast

Rhodiola is native to wild Artic climates and is a large part of many traditional medicines. It is known to reduce stress levels, decrease fatigue, and promote energy (Ishaque, 2010). It is a common constituent in energy and anti-fatique-based nootropic stacks (Zhang, 2009). It is frequently used by entrepreneurs to improve their overall alertness and focus.

Taurine

Taurine is commonly found in energy drinks. It is extracted from animal tissue, such as its original biosynthesis from ox bile (Tiedemann and Gmelin, 1827). It is also an antioxidant, helping the body to rid itself of cell-damaging free radicals (Xu, et al., 2008).

Tyrosine

Tyrosine is one of the body’s standard non-essential amino acids used to synthesize proteins. Although it is rather weak in terms of noticeable effects, it is a neurotransmitter precursor that stimulates the production of dopamine and norepinephrine (Rasmussen, 1983).

Valarian Root Ingredient Found in Pirate Chill

Valarian (Valeriana officinalis) is a sweet smelling plant that is native to Europe and Asia. Two primary alkaloids of interest, valerianine and valerine work by binding to the brain’s GABA receptors. Valarian is used in nootropic supplements for its calming, sedative, and peaceful effects (James, 2003).

Vinpocetine

Vinpocetine is a synthetic derivative, ultimately created from Vincamine extracted from Voacanga africana seeds. It is typically used to treat post-stroke victims, and people suffering from various forms of dementia (Liu, et al., 2019)(Zhang, 2018). While it has been proven that it does provide some cognitive benefits to those who already suffer cognitive impairments of some kind, there are very few studies which support these same cognitive benefits for healthy individuals.

Yerba Mate

Yerba Mate is native to South America and is traditionally brewed into a beverage. It is very commonly ingested to improve metabolic health and overall mood (Alkhatib and Atcheson, 2017). A more relaxed state of mind can help an entrepreneur maintain focus, work longer, and achieve more. Containing a small amount of caffeine, it is perhaps one of the best ways to ingest caffeine for its positive benefits, with none of the negatives side effects (Ghezelbash, 2020).

Yohimbe Ingredient Found in Pirate Blast

Yohimbe comes from the bark of one of two trees located in Africa or South America only. Yohimbe is very frequently used for its ability to increase blood flow. It is used to decrease impotence, improve athletic performance, enhance weight loss efforts, and so much more (NIH, 2016). Yohimbine, the primary constituent alkaloid in Yohimbe, is known to induce noradrenergic stimulation which enhances memory consolidation (Wingenfeld, et al., 2013).

A Few Words About Caffeine, Aniracetam, and Others

Caffeine is often considered to be a nootropic. The definition of nootropic literally states that there are no negative side effects to using nootropics, but many people experience adverse reactions from using caffeine (Temple, et al., 2017). While there are some positive benefits from using caffeine for most people, some people experience cardiovascular function impairments, sleep deprivation, and other problems (2017). Still, many sites will claim caffeine as a nootropic, erroneously. And despite the benefits many people receive from caffeine intake, it will never be a true nootropic.

Aniracetam was long thought to improve cognitive function and memory in human beings. It has also been credited for improving learning as well. The studies which have backed up the idea that aniracetam improves learning, are on subjects which have a cognitive impairment. Many recent studies have painted a different picture, investigating the effects of aniracetam on healthy minds instead. These studies have revealed the substance to have no positive effect on learning, memory, or cognitive function (Reynolds, 2018) (Phillips, 2019).

Using Nootropic Supplements Effectively

Effective Nootropic Supplements for Entrepreneurs

Entrepreneurs put in so many hours and so much work that it makes the most sense to maximize efficiency within reasonable means. The top combinations of nootropic stacks are one of the best ways to make the most use of time as an entrepreneur (Denton, 2017). Whether the stack is devised to create energy or enhance focus, or to improve fluid intelligence, having a daily regimen most certainly gives the entrepreneur a significant advantage (Suliman, et al., 2016). And with the wide variety of information available, it has become easier than ever for any entrepreneur to select the proprietary blend that works best for them!

References:

Abbai, R., Mathiyalagan, R., Markus, J., Yeon-Ju, K., Wang, C., Singh, P., . . . Yang, D. C. (2016). Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng. International Journal of Nanomedicine, 11, 3131-3143. doi:http://dx.doi.org.ezproxy.liberty.edu/10.2147/IJN.S108549

Alkhatib, A., & Atcheson, R. (2017). Yerba Maté (Ilex paraguariensis) Metabolic, Satiety, and Mood State Effects at Rest and during Prolonged Exercise. Nutrients, 9(8), 882. https://doi.org/10.3390/nu9080882

Angel, B., (October 30, 2018). Unstoppable: A 90-Day Plan to Biohack Your Mind and Body for Success. Entrepreneur Press. ASIN: B07GJSNTH9. Pp. 89-92.

Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998;3(4):271-280.

Blokland, A., and Sambeth, A., (2016). The Effects of a Combination of Nootropic Ingredients on Cognition in Healthy Young Volunteers. ClinicalTrials.gov. Retrieved from: https://clinicaltrials.gov/ct2/show/NCT02857829

Cohen, J., (December 15, 2019). 12 Health Benefits of Ginseng. Self Hacked. Retrieved from: https://selfhacked.com/blog/ginseng/

Cronkleton, E., (March 7, 2019). 10 Benefits of Lemon Balm and How to Use It. Healthline. Retrieved from: https://www.healthline.com/health/lemon-balm-uses

Denton, M., (2017). Every Entrepreneur Needs Flow. Nootropics Can Get You There. Entrepreneur.com. Retrieved from: https://www.entrepreneur.com/article/296087

Ghezelbash, P., (2020). Yerba Mate as a Nootropic: A Simple, Science-Based Review. Nootropics Resources. Retrieved from: https://nootropicsresources.com/yerba-mate/

Giurgea CE, Greindl MG, Preat S. Nootropic drugs and aging. Acta Psychiatr Belg. 1983;83(4):349-358.

Godsey, C., Horowitz, D., and Sather, R., (2020). Green Tea Extract University of Rochester Medical Center. Rochester, NY. Retreived from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=19&contentid=GreenTeaExtract

Gohil, K. J., Patel, J. A., & Gajjar, A. K. (2010). Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all. Indian journal of pharmaceutical sciences, 72(5), 546–556. https://doi.org/10.4103/0250-474X.78519

Gouliaev AH Senning A Piracetam and other structurally related nootropics. Brain Res Rev. 1994; 19: 180-222.

Hinz, M., Stein, A., & Uncini, T. (2012). 5-HTP efficacy and contraindications. Neuropsychiatric disease and treatment, 8, 323–328. https://doi.org/10.2147/NDT.S33259

Ishaque, S., Shamseer, L., Bukutu, C., (2012). Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complement Altern Med 12, 70. https://doi.org/10.1186/1472-6882-12-70

James, S. (2003). Herbal and OTC Sleep Remedies: Implications for Psychiatry. The Psychiatric Times., 20(12).

Karalija, A., Novikova, L., Kingham, P., Wiberg, M., and Novikov, L., (2012). Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats. PLoS ONE. ISSN: 1932-6203. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398872/pdf/pone.0041086.pdf/?tool=EBI

Keiko Unnoa, b, Hiroshi Yamadac, & Kazuaki Iguchia. (2017). Anti-stress Effect of Green Tea with Lowered Caffeine on Humans : A Pilot Study. Biological & Pharmaceutical Bulletin., 40(6), 902–909.

Lapin I. (2001). Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug. CNS drug reviews, 7(4), 471–481. https://doi.org/10.1111/j.1527-3458.2001.tb00211.x

Liu, Y., Yin, Y., Lu, Q., Dan, Y., Xu, M., Song, G., & Li, C. (2019). Vinpocetine in the treatment of poststroke cognitive dysfunction. Medicine., 98(6). https://doi.org/10.1097/MD.0000000000013685

Lopresti, A., Smith, S., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. Medicine., 98(37). https://doi.org/10.1097/MD.0000000000017186

Mahadevan, S. and Park, Y. (2008), Multifaceted Therapeutic Benefits of Ginkgo biloba L.: Chemistry, Efficacy, Safety, and Uses. Journal of Food Science, 73: R14-R19. doi:10.1111/j.1750-3841.2007.00597.x

Malykh, A. G., & Sadaie, M. R. (2010). Piracetam and piracetam-like drugs: From basic science to novel clinical applications to CNS disorders. Drugs, 70(3), 287-312. doi:http://dx.doi.org.ezproxy.liberty.edu/10.2165/11319230-000000000-00000

NCCIH (September 2016). Passionflower. National Center for Complementary and Integrative Health. Retreived from: https://www.nccih.nih.gov/health/passionflower

NIH (September, 2016). Yohimbe. National Center for Complementary and Integrative Health. Retrieved from: https://www.nccih.nih.gov/health/yohimbe

Olsen R., and Betz, H. (2006). GABA and Glycine. Basic Neurochemistry: Molecular, Cellular and Medical Aspects (7th ed.). Elsevier. pp. 291–302.

Pase M., Kean J., Sarris J., Neale, C., Scholey A., Stough C., (2012). The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. 2012;18:647–652.

Peixoto, H., Roxo, M., Röhrig, T., Richling, E., Wang, X., & Wink, M. (2017). Anti-Aging and Antioxidant Potential of Paullinia cupana var. sorbilis: Findings in Caenorhabditis elegans Indicate a New Utilization for Roasted Seeds of Guarana. Medicines (Basel, Switzerland), 4(3), 61. https://doi.org/10.3390/medicines4030061

Phillips, H., McDowell, A., Mielby, B., Tucker, I., and Colombo, M., (April 19, 2019). Aniracetam does not improve working memory in neurologically healthy pigeons. PLoS One. Retrieved from: https://doi.org/10.1371/journal.pone.0215612

Rasmussen, D., Ishizuka, B., Quigley, M., Yen, S., (1983). Effects of Tyrosine and Tryptophan Ingestion on Plasma Catecholamine and 3,4-Dihydroxyphenylacetic Acid Concentrations. The Journal of Clinical Endocrinology & Metabolism. Vol (57). Iss (4). Pp. 760–763.

Reynolds CD, Jefferson TS, Volquardsen M et al. Oral aniracetam treatment in C57BL/6J mice without pre-existing cognitive dysfunction reveals no changes in learning, memory, anxiety or stereotypy [version 3; peer review: 2 approved, 1 approved with reservations]. F1000Research 2018, 6:1452 (https://doi.org/10.12688/f1000research.11023.3)

Scholey, A., Gibbs, A., Neale, C., Perry, N., Ossoukhova, A., Bilog, V., . . . Buchwald-Werner, S. (2014). Anti-stress effects of lemon balm-containing foods. Nutrients, 6(11), 4805-4821. doi:http://dx.doi.org.ezproxy.liberty.edu/10.3390/nu6114805

Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev. 2002;(1):CD003198. doi:10.1002/14651858.CD003198

Strugała, P., Gładkowski, W., Kucharska, A.Z., Sokół‐Łętowska, A. and Gabrielska, J. (2016), Antioxidant activity and anti‐inflammatory effect of fruit extracts from blackcurrant, chokeberry, hawthorn, and rosehip, and their mixture with linseed oil on a model lipid membrane. Eur. J. Lipid Sci. Technol., 118: 461-474. doi:10.1002/ejlt.201500001

Suliman, N. A., Mat Taib, C. N., Mohd Moklas, M. A., Adenan, M. I., Hidayat Baharuldin, M. T., & Basir, R. (2016). Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic. Evidence-based complementary and alternative medicine : eCAM, 2016, 4391375. https://doi.org/10.1155/2016/4391375

Sun, W. 1998. Ginkgo biloba. The IUCN Red List of Threatened Species 1998: e.T32353A9700472. https://dx.doi.org/10.2305/IUCN.UK.1998.RLTS.T32353A9700472.en. Downloaded on 17 July 2020.

Swonson, J., (2018). Acetyl-L-carnitine: Can it relieve MS fatigue? Mayo Clinic. Retrieved from: https://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/expert-answers/acetyl-l-carnitine/faq-20057801

Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017). The Safety of Ingested Caffeine: A Comprehensive Review. Frontiers in psychiatry, 8, 80. https://doi.org/10.3389/fpsyt.2017.00080

Tiedemann, F. and Gmelin, L. (1827), Einige neue Bestandtheile der Galle des Ochsen. Ann. Phys., 85: 326-337. doi:10.1002/andp.18270850214

Wang, S., Xu, J., Zheng, J., Zhang, X., Shao, J., Zhao, L., & Hao, J. (2020). Anti-Inflammatory and Antioxidant Effects of Acetyl-L-Carnitine on Atherosclerotic Rats. Medical science monitor : international medical journal of experimental and clinical research, 26, e920250. https://doi.org/10.12659/MSM.920250

Weinberg-Wolf, H., Fagan, N.A., Anderson, G.M. et al. The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque. Neuropsychopharmacol 43, 1589–1598 (2018). https://doi.org/10.1038/s41386-017-0003-7

Wessinger, C., (2018). Effect of Huperzine A on Cognitive Function and Perception of Effort During Exercise U.S. National Library of Medicine. ClinicalTrials.gov. Retrieved from: https://clinicaltrials.gov/ct2/show/NCT03445104

Westphalen, D., (2019). What Does Gamma Aminobutyric Acid (GABA) Do? Healthline. Retrieved from: https://www.healthline.com/health/gamma-aminobutyric-acid

Wiley, M., (January 29, 2019). 5 Brain Boosting Benefits of Lions Mane Mushroom. Botanical Health. Retrieved from: https://botanicahealth.com/blog/5-brain-boosting-benefits-of-lions-mane/

Wingenfeld K, Kuffel A, Uhlmann C, et al. Effects of noradrenergic stimulation on memory in patients with major depressive disorder. Stress. 2013;16(2):191-201. doi:10.3109/10253890.2012.708951

Xu, Y. J., Arneja, A. S., Tappia, P. S., & Dhalla, N. S. (2008). The potential health benefits of taurine in cardiovascular disease. Experimental and clinical cardiology, 13(2), 57–65.

Yue, J., Dong, B. R., Lin, X., Yang, M., Wu, H. M., & Wu, T. (2012). Huperzine A for mild cognitive impairment. The Cochrane database of systematic reviews, 12(12), CD008827. https://doi.org/10.1002/14651858.CD008827.pub2

Zainullina, L.F., Ivanova, T.V., Ostrovskaya, R.U. et al. Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation. Bull Exp Biol Med 166, 466–468 (2019). https://doi-org.ezproxy.liberty.edu/10.1007/s10517-019-04373-8

Zhang, Y., Li, J., and Yan, C., (January 15, 2018). An update on vinpocetine: New discoveries and clinical implications. European Journal of Pharmacology. Vol. (819). Pp. 30-34.

Zhang ZJ; Tong Y; Zou J; Chen PJ; Yu DH, (2009). Chinese journal of integrative medicine.Vol. 15 (3), pp. 177-83; Publisher: Chinese Journal of Integrated Traditional and Western Medicine Press ; PMID: 19568709;

Image Credits:

Entrepreneur Working Hard [ID 184790447 © Airdone | Dreamstime.com]

Can Nootropics Be Used Togther [ID 108034344 © Catalin205 | Dreamstime.com]

Using Nootropics [ID 104778450 © Blanscape | Dreamstime.com]

How Does The Brain Benefit From Nootropics

Do Nootropics Work as Vitamins for the Brain

Are Nootropics Like Brain Vitamins?

Nootropics do all types of things for the mind and body. Technically, they are substances that provide a mental boost of some kind, while offering no negative effects. While this may sound like a godsend, ultimately, there are thousands of nootropics in the world. The truth is, only a few of them are worth mentioning in terms of providing dramatic benefits to the mind. There are definitely nootropics which function like brain vitamins, and they can contribute to significant positive impacts in one’s life. Additionally like vitamins, many nootropics are used daily. The mind and body become used to the nootropics and the benefits become permanent. Many nootropic enthusiasts tend to look at this process as a way of training or teaching the brain to function more efficiently. Still, it greatly benefits all nootropics users to understand how they are working, and how they are broken down in the mind and body.

How Do Nootropics Affect the Brain?

Nootropics work by encouraging the brain to function in an improved manner, either by manipulating the production of, or the reduction of, certain neurotransmitters (or brain chemicals). They are typically neuroprotective substances, that help the brain identify with better thinking and resting practices.1 This is a list of some of the most effective nootropics that function like brain vitamins, and their affects on the brain:

  • Huperzine A: Regularly revered for its outstanding memory-enhancing, and thinking-enhancing properties. It is often considered a super nootropic in terms of brain boosters.2
  • Hawthorn: A powerful adaptogen, giving the mind a chance to relax and attain a state of clarity and reduced stress. Adaptogens are important, natural ways to calm the mind and promote more focused thinking.
  • Ginseng: Well-known for its ability to promote stimulated thinking, as well as more mental and physical energy.
  • Green Coffee Bean: This is a wildly under-rated nootropic capable of providing amazing anti-oxidant and energizing properties. It is one of the strongest natural caffeine sources available.
  • Rhodiola: An excellent natural source for energy, of which can be applied in the mind in terms of thinking power.3
  • Yohimbe: Great for energy and promoting blood flow. More blood flow can lead to overall better functioning of the brain.
  • Vinpocetine: Often selected for its energizing properties.
  • Bacopa Monnieri: Used for its relaxing and calming properties. Although it is a less-potent nootropic, it is often included in many stacks.4
  • Ashwagandha: Used in many calming formulas. Has a long history throughout many cultures of being used for its relaxation properties.
  • Gotu Kola: Gotu Kola is a source of natural caffeine and promotes an awakened, energized state, and able to improve cognitive function.5
  • GABA: Often selected for its relaxation and calming properties.
  • L-Theanine: A very strong calming and relaxation nootropic. Sometimes used in combination with caffeine, as well as other nootropics, to create a focused boost in the mind.
  • Passion Flower: Frequently chosen for its calming effects on the mind. It is used in some of the most powerful relaxation formulas in the world.6

Many nootropics work better when used in combination with other nootropics.1 This is why many nootropic stacks and proprietary blends include a combination of ingredients to achieve the desired effects on the mind. Simply put, there are many nootropics which work best together. Still, there are some nootropics which you would never want to combine together. And even moreso, there are certain nootropics which will function better when taking alone altogether.

Long Term Effects of Nootropics on the Brain

Many substances have a “use in moderation” rule, including even innocuous substances like coffee, sugar, and salt. Similarly, most nootropics only require a small daily serving size in order to achieve the desired benefits. Very rarely are there benefits from overusing nootropics. With that said, however, most nootropics still work best as they are built up in the system. Using the same nootropics on a residual basis over a long time helps the body and brain understand their effects better. In fact, most studies provide evidence that long term nootropic use provides positive effects on the brain and in the body.1

Regardless, some of the most important nootropics have proven to improve overall function, as well as many specific functions in the brain over time.1,4 Some of the most successful “brain nootropics” include: Huperzine A, Hawthorn, Ginseng, Rhodiola, Yohimbe, Vinpocetine, Bacopa Monnieri, Ashwagandha, Gotu Kola, GABA, L-Theanine, and Passion Flower.

Tips for Using Nootropics Long-Term

Remember, nootropics work best as a part of a daily regimen. Many nootropics and proprietary blends, like Pirate Botanicals products, work best as they build up in the system. For example, Piratall is a brain nootropic supplement that provides more benefits as it is used over the course of time. This is why the product comes in a 30 days supply bottle, because it is meant to be taken every day. Piratall is a great example of a brain vitamin, containing natural caffeines (from Green Coffee Bean extract and Guarana extract), as well as long-term adaptogens, anti-oxidant properties, and mind-boosting properties (from things like Huperzine A). Pirate Botanicals created Piratall as a way to maximize the benefits of nootropics in the brain as quickly as possible, as well as in a compounding fashion over time.

Disclaimer: Always consult your physician before adding new supplements to your diet, or making any major changes to your diet.

Citations:

1Frati, P., Kyriakou, C., Del Rio, A., Marinelli, E., Vergallo, G. M., Zaami, S., and Busardo, F. P.. (2015). Smart Drugs and Synthetic Androgens for Cognitive and Physical Enhancement: Revolving Doors of Cosmetic Neurology. Current Neuropharmacology. Vol. 13(1) pp 5-11, 7.

2Tun, M. K., & Herzon, S. B. (2012). The pharmacology and therapeutic potential of (-)-huperzine A. Journal of experimental pharmacology, 4, 113–123. doi:10.2147/JEP.S27084

3Ross, S.. (April 2014). Rhodiola rosea. Holistic Nursing Practice. Vol. 28(2). pp. 149-154.

4Aguiar, S., & Borowski, T. (2013). Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation research, 16(4), 313–326. doi:10.1089/rej.2013.1431

5Farhana, K. M., Malueka, R. G., Wibowo, S., & Gofir, A. (2016). Effectiveness of Gotu Kola Extract 750 mg and 1000 mg Compared with Folic Acid 3 mg in Improving Vascular Cognitive Impairment after Stroke. Evidence-based complementary and alternative medicine : eCAM, 2016, 2795915. doi:10.1155/2016/2795915

6Meier, S., Haschke, M., Zahner, C., Kruttschnitt, E., Drewe, J., Liakoni, E., Hammann, F., and Gaab, J.. (January 15, 2018). Effects of a fixed herbal drug combination to an experimental acute stress setting in healthy men. Phytomedicine. Vol. 39. Pp. 85-92

Nootropics for Entrepreneurs (Using Nootropics as an Entrepreneur)

Nootropics Used by Entrepreneurs & The Benefits

nootropics used by entrepreneurs

Why Do Entrepreneurs Use Nootropics?

Entrepreneurs are some of the hardest working individuals on the face of the planet. Any real entrepreneur will vouch for the extreme difficulty this career choice brings about. Working hard requires a huge number of favorable intellectual and physical attributes. Fortunately, however, most of the necessary attributes of a successful entrepreneur can be influenced by the right nootropic stacks. Nootropics have a lot of built-in benefits that help entrepreneurs get the most out of their thinking power, memory, energy and drive. Nootropics are even able to improve fluid intelligence, which can make entrepreneurs better problem solvers. The impact nootropics have on memory (crystallized intelligence) is also incredibly beneficial to entrepreneurs. Although it is never easy to be creative, persistent, or productive, nootropics can help with that too! No matter the type of entrepreneur or business, the right nootropics have been proven to be able to turn a mental road block into creative genius.1

So what is it about an entrepreneur that makes them so susceptible to the benefits of nootropics? To better understand why entrepreneurs benefit so greatly from nootropics, it is best to begin looking at what makes an entrepreneur so different in general.

What Makes An Entrepreneur’s Brain Different?

entrepreneurs have different brains

Many studies have proven that an entrepreneur naturally thinks differently than most other people.9,10 Besides the studies, it has always been clear that entrepreneurs choose less commonly walked paths. The most famous successful people and most influential creative geniuses of all time are easy models of the entrepreneur way of thinking, including but not nearly limited to: Henry Ford, Andrew Carnegie, Bill Gates, Larry Page, Steve Jobs, Walt Disney, Oprah Winfrey, John D. Rockefeller, Thomas Edison, Benjamin Franklin, Nikola Tesla, and even Shakespeare. A quick look at any of their lives will show profound risk, insane dedication to work, and a drive to push the barriers farther than they have ever been pushed before! Many of them sacrificed everything they had in order to make a difference and create an impact. And many of them took their work so seriously, they would do anything to get ahead.

But why? What makes the entrepreneur’s brain so different than that of the norm to suggest these strides of creativity and risk? The answer lies within the science of the brain and an entrepreneur’s innate ability to create.10

Science Proves Entrepreneurs Think Differently

Plenty of data and a number of scientific studies have proven an entrepreneur thinks differently.9,10 In fact, there is an entire theorem called “Effectual Reasoning” which was developed in order to define the way entrepreneurs think. Basically, Effectual Reasoning is the ability and desire to solve problems and improve the state of the world by creating, innovating and enabling the creativity of firms, ideas, markets, products, and services.11 The term was created to define the successful strategies of 27 founders of companies that had attained a successful net worth of at least $200M, although it included many billion dollar companies as well.

There are many parts of effectuation which are used to describe the successful entrepreneurial mindset, including the idea to use common logic in order to find solutions to problems. Probably the most interesting part of an entrepreneurial mindset is their ability to use variables as possibilities for new outcomes. This of course comes opposed by the theory of casual thinking, or the idea that the variables limit the outcome.11

many successful entrepreneurs use nootropics and smart drugs

In plain terms: entrepreneurs see lemons as the ability to create lemonade, or also citrus extract, or a seasoning for a meal, or possibly an entirely new way to use a lemon. Entrepreneurs are so good at creating new things that they usually will pursue them even when the resources for the opportunities are uncontrolled! They also think in form of massive action (and in form of taking action at all!). This means that while casual thinkers spend a lot of time planning, entrepreneurs will spend much more time taking the right actions.12

Another really common trend in most of the interviews and articles about successful entrepreneurial traits includes the value of time. Most entrepreneurs recognize how valuable their time is and try to find ways to transform their time into greater value. They take exceptional pride in saying “no” to opportunities which will not benefit them and pursuing things of the greatest value alone.13 And finally, entrepreneurs are not afraid of hard work, spend a lot of time practicing great discipline (and working hard), are passionate about what they do, and always challenge the status quo!14

Entrepreneurs have to think harder and the choice demands maximum creativity. Fortunately, nootropics can create a better balance in the brain, and finding the most effective nootropics for entrepreneurs is as easy as understanding the biggest deficiencies entrepreneurs face.

Nootropics Used By Entrepreneurs

So many types of nootropics exist. There are nootropics which help build stamina and energy.6 There are nootropics which improve memory formation and recall.2,3 There are nootropics for improving mood and relieving stress.4 Nootropics exist for improving all types of cognitive function and physical performance.5,6,7,8 The best nootropics for entrepreneurs are those which focus on attributes most used by entrepreneurs. Nootropics used by entrepreneurs tend to improve focus and attention span, memory, thinking power and fluid intelligence, energy, and motivation. It is imperative that the nootropics all work properly together as well (some nootropics would be silly to use together). In short, entrepreneurs need nootropics that focus on providing effective cognitive boosts with absolutely no excessive junk ingredients.

What Are The Best Nootropics For Entrepreneurs?

This is a list of the nootropics most commonly selected by entrepreneurs. This list is in order of overall value and only includes nootropics which improve cognitive function over the course of use.

Huperzine A

huperzine helps produce acetylcholine in the brain

Many studies show Huperzine as an effective nootropic for improving memory.3,5 It works so well, in fact, it is commonly used for treatment of various forms of dementia.5 Huperzine has been well known for many years to improve cognition and thinking.15 It has also been used for centuries throughout various cultural medicines around the world, even being considered a part of ancient Chinese medicine. Huperzine is so effective at improving cognitive performance because of its ability to easily cross the blood-brain barrier. This ultimately allows Huperzine to influence the brain’s chemical production. Huperzine A works by limiting AChE, the primary inhibitor of acetylcholine;16 And acetylcholine is a powerful and important neurotransmitter in terms of memory and cognitive performance.17

Possessing a strong memory and impressive cognitive function are imperative in achieving an entrepreneur’s fullest thinking potential. Huperzine A can help an entrepreneur achieve their strongest, natural cognitive performance and all around sharpest memory!

Huperzine A is found in the Piratall and Pirate Blast formulae.

Siberian Ginseng

Ginseng is very commonly used as a stimulant in addition to its antioxidant properties.8 Ginseng is also a well-known actoprotector. Actoprotectors are extracts or preparations that enhances body stability against physical loads, while increasing overall mental performance. Many studies have shown that Ginseng can significantly increase physical and intellectual work capacity.18 Ginseng has also been shown to have incredible antioxidant properties and studies have proven its efficacy in combating chronic fatigue.19 Siberian ginseng (aka Eleuthero) is one of the most potent adaptogenic herbs, which means it helps the body with stress, and promotes overall health.20 Ginseng is primarily used by entrepreneurs for its potent properties as a brain function stimulant.23

Siberian Ginseng is found in the Piratall formula.

Hawthorn

Hawthorn (Crataegus extract) has been used in traditional medicine for thousands of years. Many recent studies have begun finding the health benefits of Hawthorn to be extremely impressive.21,22 In fact, one study showed an improvement in overall health-related quality of life.21 Another investigation into Hawthorn has revealed its phytonutrients (anthocynidins and proanthocyanidins) to be powerful antioxidants. These phytonutrients also help strengthen the walls of blood vessels and improve blood flow.22

Hawthorn is found in the Piratall formula.

Rhodiola Rosea

using rhodiola for entrepreneurial nootropic stacks

Rhodiola rosea is used to improve physical and mental stamina, and to increase energy. It is used very frequently to combat stress and provides a lot of antioxidant properties. Rhodiola is known to be a legal stimulant. It contains components which increase production of norepinephrine, serotonin, dopamine, and acetylcholine. Ultimately, Rhodiola helps improve focus, concentration, memory, intellectual capacity and overall fatigue resistance.23

Rhodiola is found in the Pirate Blast formula.

L-Theanine

L-theanine is very commonly included in stress-oriented studies, for its incredible de-stressing and relaxing properties.4 L-Theanine improves antioxidant and neuroprotective activity.24 It has been used to improve mood, reduce mental fatigue, and eliminate irritability. By relaxing the adrenals, the mind can de-stress and L-Theanine can work up natural energy levels.25 It is often used in combination with other nootropics as it helps bolster the positive benefits of the nootropic stack as a whole.

L-Theanine is found in the Pirate Chill formula.

Guarana

Guarana contains more caffeine than most plants on Earth, even more than the coffea plant.23 It is very commonly used for energy and produces a natural caffeine, rather than the synthetic caffeine crammed into most energy drinks. Natural caffeine, like that from Guarana, activates the central nervous system without the same crashes brought about from caffeine anhydrous. Guarana is one of the most used nootropics by entrepreneurs for its ability to increase mental vigilance and improve fatigue resistance.23

Guarana seed has even been proven to offer additional stimulation effects aside from those caffeine has to offer!6

Guarana seed extract is found in the Piratall and Pirate Blast formulae.

Passion Flower

passion flower is a great nootropic for entrepreneur stacks

Passion Flower (Passiflora incarnata) is used for its powerful sedative properties. The sedative effects of Passion Flower come from its GABAergic properties. In fact, it works so well that it has been commonly used to treat neuropathic pains.26 Passiflora has been proven to possess anxiolytic effects (the ability to reduce anxiety, chiefly via drug),27 which is extremely useful for the demanding, high-stress lifestyle of an entrepreneur.

Passion Flower is found in the Pirate Chill formula.

Conclusion: Nootropics and Entrepreneurs

Entrepreneurs understand better than most people that accepting the bare minimum is unacceptable; and that there are always ways for people to get more out of their time and energy. Nootropics are so frequently used by entrepreneurs because they are one of the best ways to get the most out of their time. The secret to the efficacy of nootropic stacks are their abilities to increase the productivity of the brain, allowing an entrepreneur the best chance to operate at their peak cognitive performance. Traditionally, entrepreneurs seemed to seek a prescription for smart drugs or legal stimulants (adderall, modafinil, etc.), however, an increasing number of entrepreneurs every day are realizing nootropic stacks are a better alternative to prescription smart drugs. Because nootropics are so effective and available to anyone, they have become the preferred solution for many entrepreneurs (and a strongly attractive option). And many entrepreneurs are realizing much greater productivity from using nootropics than ever before!

Looking for more information as to which Pirate Botanicals Nootropic Supplement is right for you? Check out our Supplement Selector Tool or contact us for help!

Sources:

1Jelic, V., Kivipelto, M., & Winblad, B. (2005). Clinical trials in mild cognitive impairment: lessons for the future. Journal of neurology, neurosurgery, and psychiatry, 77(4), 429-38.

2Aksenov, V., Long, J., Liu, J., Szechtman, H., Khanna, P., Matravadia, S., & Rollo, C. D. (2011). A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice. Age (Dordrecht, Netherlands), 35(1), 23-33.

3Malkova, L., Kozikowski, A. P., & Gale, K. (2010). The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. Neuropharmacology, 60(7-8), 1262-8.

4White, D. J., de Klerk, S., Woods, W., Gondalia, S., Noonan, C., & Scholey, A. B. (2016). Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients, 8(1), 53. doi:10.3390/nu8010053

5Tun, M. K., & Herzon, S. B. (2012). The pharmacology and therapeutic potential of (-)-huperzine A. Journal of experimental pharmacology, 4, 113-23. doi:10.2147/JEP.S27084

6Kotta, S., Ansari, S. H., & Ali, J. (2013). Exploring scientifically proven herbal aphrodisiacs. Pharmacognosy reviews, 7(13), 1-10.

7Moustakas, D., Mezzio, M., Rodriguez, B. R., Constable, M. A., Mulligan, M. E., & Voura, E. B. (2015). Guarana provides additional stimulation over caffeine alone in the planarian model. PloS one, 10(4), e0123310. doi:10.1371/journal.pone.0123310

8Kotta, S., Ansari, S. H., & Ali, J. (2013). Exploring scientifically proven herbal aphrodisiacs. Pharmacognosy reviews, 7(13), 1-10.

9Halko, M. L., Lahti, T., Hytönen, K., & Jääskeläinen, I. P. (2017). Entrepreneurial and parental love-are they the same?. Human brain mapping, 38(6), 2923-2938.

10Long, Michael E. and Lieberman, Daniel Z., (September 2018). Entrepreneurs’ Brains Are Wired Differently. Here’s How to Use Yours Right. ENTREPRENEUR MINDSET Retrieved from: https://www.entrepreneur.com/article/319761 Accessed On December 5, 2018.

11The Society for Effectual Action, (2018). Effectuation 101. Effectuation.org. Retreived from https://www.effectuation.org/?page_id=207 Accessed on December 8, 2018.

12Baskerville, P., (November 5, 2013). How Do Entrepreneurs Think? Forbes.com. Retrieved from: https://www.forbes.com/sites/quora/2013/11/05/how-do-entrepreneurs-think/#1088949a3905 Accessed on December 8, 2018.

13Constable, K., (January 5, 2016). 3 Ways Successful Entrepreneurs Think Differently. Entrepreneur Mindset. Retrieved from: https://www.entrepreneur.com/article/254216 Accessted on December 8, 2018.

14Patel, S., (September 9, 2017). 9 Ways Entrepreneurs Think Differently Than Employees. INC.com Retrieved from: https://www.inc.com/sujan-patel/9-ways-entrepreneurs-think-differently-than-employ.html Accessed on December 8, 2018.

15Zhang, Z., Wang, X., Chen, Q., Shu, L., Wang, J., and Shan, G., (July 01, 2002). Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial. Europe PMC. Retrieved: https://europepmc.org/abstract/med/12181083 Accessed on December 8, 2018.

16English, J., (August 20, 2014). Huperzine: Advanced Herbal Support for Memory and Cognitive Function. Nutrition News. Retrieved from: https://nutritionreview.org/2014/08/huperzine-protecting-memory-cognitive-function/ Accessed on December 8, 2018.

17Haam, J., & Yakel, J. L. (2017). Cholinergic modulation of the hippocampal region and memory function. Journal of neurochemistry, 142 Suppl 2(Suppl 2), 111-121.

18Oliynyk, S., & Oh, S. (2013). Actoprotective effect of ginseng: improving mental and physical performance. Journal of ginseng research, 37(2), 144-66.

19Kim, H. G., Cho, J. H., Yoo, S. R., Lee, J. S., Han, J. M., Lee, N. H., Ahn, Y. C., … Son, C. G. (2013). Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial. PloS one, 8(4), e61271. doi:10.1371/journal.pone.0061271

20Winston, D. and Maimes, S., (2018). Adaptogens: Herbs for Strength, Stamina, and Stress relief. Retrieved from: http://www.manumu.no/Customers/janerik2/documents/pdf%20boeker/Excerpt_Excerpt_Adaptogens.pdf Accessed on December 9, 2018.

21Holubarsch, C. J. F., Colucci, W.S., and Eha, J., (February, 2018). Benefit-Risk Assessment of Crataegus Extract WS 1442: An Evidence-Based Review. American Journal of Cardiovascular Drugs. Volume 18(1). Pp 25-36. Retrieved From: https://www.ncbi.nlm.nih.gov/pubmed/29080984 Accessed on December 9, 2018.

22Weil, A., M.D., (February 12, 2014). Hawthorn. DrWeil.com. Retrieved from: https://www.drweil.com/vitamins-supplements-herbs/herbs/hawthorn/ Accessed on December 9, 2018.

23Sellami, M., Slimeni, O., Pokrywka, A., Kuvačić, G., D Hayes, L., Milic, M., & Padulo, J. (2018). Herbal medicine for sports: a review. Journal of the International Society of Sports Nutrition, 15, 14. doi:10.1186/s12970-018-0218-y

24Li, C., Yan, Q., Tang, S., Xiao, W., & Tan, Z. (2018). L-Theanine Protects H9C2 Cells from Hydrogen Peroxide-Induced Apoptosis by Enhancing Antioxidant Capability. Medical science monitor : international medical journal of experimental and clinical research, 24, 2109-2118. doi:10.12659/MSM.907660

25WorldHealth.net (December 4, 2018). Fatigue and Adrenals. World Health. Retrieved from: https://www.worldhealth.net/news/fatigue-and-adrenals/ Accesssed on December 10, 2018.

26Aman, U., Subhan, F., Shahid, M., Akbar, S., Ahmad, N., Ali, G., Fawad, K., … Sewell, R. D. (2016). Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms. BMC complementary and alternative medicine, 16, 77. doi:10.1186/s12906-016-1048-6

27Dantas, L. P., de Oliveira-Ribeiro, A., de Almeida-Souza, L. M., & Groppo, F. C. (2016). Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Medicina oral, patologia oral y cirugia bucal, 22(1), e95-e101. doi:10.4317/medoral.21140

Can Nootropics Improve Memory

Are There Real Nootropics That Can Improve Memory?

The term “Nootropics” can be used for many things, but in general is used to describe a substance that provides a cognitive boost of some kind with no negative side effects.1 Finding nootropics that are particular to giving memory-capabilities a cognitive boost is not so complicated, as many of them can contribute to improved memory. It is true though that some nootropics are more popularly used to improve memory for a reason: they are more effective.5 In fact, some nootropics are so good at improving memory, they have been prescribed to patients with mental dementia (Alzheimer’s, etc.) and related disorders.2,3 Some nootropics work best when used in combination with other nootropics.8,18 This is often why nootropic stacks and nootropic-inspired supplements are created to give users the optimum balance of the right nootropics to generate optimum performance.

Many nootropics undoubtedly have the ability to improve long-term memory formation (Gc), or a generalized foundation for knowledge. But with that said, nootropics are not made equal and some nootropics are better than others for various applications, such as memory enhancement. Some nootropics only provide improvements to certain attributes of memory. While there are others which provide insanely strong benefits to nearly all memory formation and recall functions. In fact, some of the best nootropics for improving Crystallized Intelligence, or better memory retention, can start helping in as early as their first dose!6 And in terms of memory, there are some front runners which simply cannot be ignored!

List of Nootropics That Improve Memory and Crystallized Intelligence

Here are some of the most popular and effective nootropics for improving memory.

Huperzine A

Despite many other nootropics which have come and gone in terms of “buzz words,” Huperzine still regularly outperforms most of them. In fact, when it comes to memory, Huperzine A has one of the oldest histories of use and most substantial tract records available in research! Huperzine A helps people who have deficient levels in ACh by inhibiting AChE. AChE stands for ACh enzymes. Allowing the ACh to build back up is critical in the formation of new memory and for proper overall cognitive function.2,10,11 Studies on Huperzine continue to prove that it is an impressive nootropic in terms of having some of the greatest positive potential impacts on spatial memory, memory impairments, and overall recall.22

Huperzine is such a powerful nootropic in terms of cognitive benefit, that it has been regularly used throughout the centuries to treat all types of Dementia (including Alzheimer’s).2 Not only has this herb been prescribed by doctors of all types for those already suffering these diseases, it has also been suggested to help prevent general mental regression and that further research is absolutely worthwhile.2,9

Siberian Ginseng

siberian ginseng has been used for centuries to improve memory

Ginseng is very widely used as a cognitive enhancing nootropic. It is frequently used for memory. In fact, some studies have revealed that the power ginseng can have on cognitive function and memory to be comparable to that of Modafinil.5 Ginseng possesses awesome ability as an adaptogen as well,16 which can help the brain maintain a calmed, balance state. Studies exist which have shown certain strains of Ginseng significantly increase intellectual work capacity.16

Ginseng has been recorded as having acute positive effects on secondary memory and even heavier cognitive memory-related tasks.5,15 Siberian Ginseng is one of the most revered strains of Ginseng. It contains powerful nanoparticles that are considered super-efficient antioxidants (among other profound applications).19

Hawthorn

Stress can have a significant impact on one’s ability to perform at their peak cognitive function. Stress is absolutely able to negative impact memory functions.13 It has been proven that stress can impact the ability to properly store new memory (memory formation), as well as the ability to accurately recount details of past events. This is evident in numerous student-based studies.14

To combat mental fatigue, many people turn to adaptogens such as Hawthorn (and the previously mentioned Ginseng). This is because adaptogens can improve mental performance, including memory.16 Hawthorn is one of the most effectively-employed adaptogens and has been proven throughout studies to reduce oxidative stresses and improve memory functions.17

Piracetam

Piracetam is commonly honored in many articles and reviews for its memory and learning-improving abilities, however, it has far less effectiveness than many of the other nootropics available for memory in specific. Most notably, trials that compare Huperzine A with Piracetam have shown Huperzine A to have far higher scores.2 Still, Piracetam is used for its cognitive enhancements that improve memory formation and recall with no negative effect to motor function.6

Vinpocetine

Vinpocetine has been used in many countries around the world to enhance memory and cognitive performance.4 Many studies have been done on Vinpocetine’s effects on cognitive performance, particularly memory. It turns out that it has had a significant impact on many memory-oriented functions and has even been useful for those with mental impairments.21

Bacopa monnieri

Bacopa deserves an honorable mention. Bacopa is more so used for its relaxing nootropic properties. Still, it has absolutely been hailed in many studies as effective for cognitive enhancement, learning improvements and memory improvements.5 Bacopa’s brain-destressing properties can also be helpful in memory recall.14

Nootropics Really Can Improve Memory and Crystallized Intelligence

nootropic supplements for memory improvement

So much of the formation of Crystallized Intelligence (and therefore, memory) has to do with maintaining good brain balance (especially great ACh levels11). Therefore, it is no surprise that Huperzine is one of the better nootropics to consider for a memory-improvement regimen. Although, many other nootropics exist which can help contribute to improving memory and memory recall. Some of these nootropics worth mentioning include: Ginkgo Biloba, L-Theanine, Guarana, and Lion’s Mane Mushroom.7,8,12 L-Theanine, for example, works great for relaxing the mind so it can achieve a greater functioning potential (including improvements to memory functions). This is especially true when used in combination with caffeine, both in their appropriate dosages.8 Therefore, using a supplement that provides a natural source of caffeine, such as Green Coffee Bean Extract and/or Guarana, along with a supplement that provides L-Theanine, can have awesomely stimulating effects on the mind’s ability to process thought and record memory.

There are many studies that provide irrefutable evidence that some nootropics (such as those mentioned above) have overwhelmingly positive effects on neurocognitive functions. This includes many cognitive functions from thinking and decision making to actual memory formation and recall.5,6,8

A lot of the nootropics which improve memory (Crystallized Intelligence, knowledge, or Gc) also improve Gf. And conveniently a higher Gf has been proven to lead to attaining a higher Gc.20 Basically, the two types of intelligence work together to create the most effective memory in the short-term and throughout the long-term. Selecting nootropics which improve fluid intelligence can be extremely helpful in developing better long term memory. Check out our other blog post Can Nootropics Improve Fluid Intelligence (Gf) to learn more.

Nootropic Supplements For Memory

Pirate Botanicals offers natural formulae nootropic supplements that help improve memory and the cognitive functions associated with memory. Improving Gf can improve Gc, and a lot of the supplements also provide a boost to Gf. Pirate Botanicals focuses on developing supplements that offer the best cognitive advantages in the short-term and long-term, including memory.

Check out the Pirate Botanicals Supplement Selector Tool to find a 100 percent natural supplement that is right for you. Pirate Botanicals offers premium nootropic supplements formulated using some of the most powerful nootropics for improving memory!

Disclaimer: These statements have not been approved by the FDA. None of this information is meant to substitute for a face-to-face consultation with a physician. Pirate Botanicals products are not meant to treat, cure, or diagnose any disease, illness, or condition.

Sources:

1Giurgea C (1972). Vers une pharmacologie de l’active integrative du cerveau: Tentative du concept nootrope en psychopharmacologie. Actual Pharmacol (Paris-released journal). Issue 25: 115–56

2Yang, G., Wang, Y., Tian, J., & Liu, J.-P. (2013). Huperzine A for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. PLoS ONE, 8(9), e74916. http://doi.org/10.1371/journal.pone.0074916

3Malkova, L., Kozikowski, A. P., & Gale, K. (2011). The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. Neuropharmacology, 60(7-8), 1262–1268. http://doi.org/10.1016/j.neuropharm.2010.12.018

4French, J. M. T., King, M. D., & McDougal, O. M. (2016). Quantitative determination of vinpocetine in dietary supplements. Natural Product Communications, 11(5), 607–609

5Neale, C., Camfield, D., Reay, J., Stough, C., & Scholey, A. (2013). Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: a review and comparison of effect sizes. British Journal of Clinical Pharmacology, 75(3), 728–737. http://doi.org/10.1111/bcp.12002

6File, S. E., & Hyde, J. R. (1977). The effects of piracetam on acquisition and retention of habituation [proceedings]. British Journal of Pharmacology, 61(3), 475P.

7Amieva, H., Meillon, C., Helmer, C., Barberger-Gateau, P., & Dartigues, J. F. (2013). Ginkgo Biloba Extract and Long-Term Cognitive Decline: A 20-Year Follow-Up Population-Based Study. PLoS ONE, 8(1), e52755. http://doi.org/10.1371/journal.pone.0052755

8Dodd, F. L., Kennedy, D. O., Riby, L. M., & Haskell-Ramsay, C. F. (2015). A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood. Psychopharmacology, 232(14), 2563–2576. http://doi.org/10.1007/s00213-015-3895-0

9Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., … on behalf of the American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Surgery and Anesthesia. (2011). Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke; a Journal of Cerebral Circulation, 42(9), 2672–2713. http://doi.org/10.1161/STR.0b013e3182299496

10Nade, V. S., Kawale, L. A., Valte, K. D., & Shendye, N. V. (2015). Cognitive enhancing effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on learning and memory. Indian Journal of Pharmacology, 47(3), 263–269. http://doi.org/10.4103/0253-7613.157114

11Haam, J., & Yakel, J. L. (2017). Cholinergic modulation of the hippocampal region and memory function. Journal of Neurochemistry, 142(Suppl 2), 111–121. http://doi.org/10.1111/jnc.14052

12Xirui, H., Xiaoxiao, W., Jiacheng, F., Yu, C., Ning, N., Hao, G., Linhong, H., Xiaoqiang, H., and Zefeng, Z., (April 2017). Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion’s Mane) mushroom: A review. International Journal of Biological Macromodules. Vol 97. Pp 228-236

13Ness, D., & Calabrese, P. (2016). Stress Effects on Multiple Memory System Interactions. Neural Plasticity, 2016, 4932128. http://doi.org/10.1155/2016/4932128

14Shields, G. S., Sazma, M. A., McCullough, A. M., & Yonelinas, A. P. (2017). The Effects of Acute Stress on Episodic Memory: A Meta-Analysis and Integrative Review. Psychological Bulletin, 143(6), 636–675. http://doi.org/10.1037/bul0000100

15Kim, Y.-S., Woo, J.-Y., Han, C.-K., & Chang, I.-M. (2015). Safety Analysis of Panax Ginseng in Randomized Clinical Trials: A Systematic Review. Medicines, 2(2), 106–126. http://doi.org/10.3390/medicines2020106

16Oliynyk, S., & Oh, S. (2013). Actoprotective effect of ginseng: improving mental and physical performance. Journal of Ginseng Research, 37(2), 144–166. http://doi.org/10.5142/jgr.2013.37.144

17Cuevas-Durán, R. E., Medrano-Rodríguez, J. C., Sánchez-Aguilar, M., Soria-Castro, E., Rubio-Ruíz, M. E., Del Valle-Mondragón, L., … Ibarra-Lara, L. (2017). Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents. International Journal of Molecular Sciences, 18(11), 2412. http://doi.org/10.3390/ijms18112412

18Egashira N, Ishigami N, Pu FL, et al. Theanine prevents memory impairment induced by repeated cerebral ischemia in rats. Phytother Res. 2008;22:65–68

19Abbai, R., Mathiyalagan, R., Markus, J., Kim, Y.-J., Wang, C., Singh, P., … Yang, D. C. (2016). Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng. International Journal of Nanomedicine, 11, 3131–3143. http://doi.org/10.2147/IJN.S108549

20Brown, R. E. (2016). Hebb and Cattell: The Genesis of the Theory of Fluid and Crystallized Intelligence. Frontiers in Human Neuroscience, 10, 606. http://doi.org/10.3389/fnhum.2016.00606

21Ogunrin, A. (2014). Effect of Vinpocetine (CognitolTM) on Cognitive Performances of a Nigerian Population. Annals of Medical and Health Sciences Research, 4(4), 654–661. http://doi.org/10.4103/2141-9248.139368

22Malkova, L., Kozikowski, A. P., & Gale, K. (2011). The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. Neuropharmacology, 60(7-8), 1262–1268. http://doi.org/10.1016/j.neuropharm.2010.12.018

scroll to top