Nootropic Supplements Used for Arthritis and Inflammation
Arthritis and inflammation are a common plague amongst humankind. It can affect work life and personal life, even down to the most mundane, daily activities. Some arthritis is so bad it even effects the simplest tasks, such as brushing one’s teeth or carrying in the groceries. Inflammation and arthritis can affect typing, eating, exercising, or even walking. Finding a solution can be difficult, however, there are many holistic answers, including nootropics.
Top Nootropics Used for Anti-Inflammation
These are some of the best nootropics for arthritis and inflammation.
Black Hoof Mushroom
Black Hoof Mushroom is a popular holistic herb used throughout many traditional Asian medicines (Chen et al., 2019). The mushroom is commonly used as an anti-inflammatory. It is said that the powerful anti-inflammation benefits of Black Hoof come from its well-studied flavonoid polyphenol pigments (2019). The mushroom contains potent polysaccharide-proteins which have been proven to speed up the healing process for burns, cuts, infections, and abrasions (Osinska-Jaroszuk, 2020). Black Hoof’s analgesic properties make it a wonderful choice for treating topical wounds (Chang et al., 2011). It has also been known to be able to produce immunostimulatory action (Uskokovic et al., 2020).
Ginkgo has been around for more than 190 million years, and it has found itself some wonderful roots in traditional and ancient Chinese medicine (Chevallier, 2016). It is one of the most powerful anti-inflammatory nootropics and can even reduce inflammation where nerve tissue damage is present. It has been especially helpful for people who suffer from multiple sclerosis symptoms. Its anti-inflammatory properties partially come from its ability to provide enhanced blood flow to the central nervous system. It can even support and strengthen nerve tissue (2016). The anti-inflammation effects are primarily found in its fruit and seed (Orr, 2014). Ginkgo has been referred to as a tonic for the body (2014). It is also known for its ability to significantly decrease oxidative stress and reduce neuroinflammation (Kaur et al., 2018).
Huperzine A comes from the club moss plant and is a powerful contributor to traditional Chinese medicine (Zangara, 2003). The extract has been used to treat fever and general inflammation for hundreds of years (Qian & Ke, 2014). In fact, there are many studies which show the plant’s genuine efficacy in reducing fever (Skolnick, 1997). There are also studies which prove its ability to reduce chronic inflammation (Wang et al., 2009). It has also been shown to offer neuroprotective properties (Wang et al., 2008).
Lion’s Mane Mushroom
Lion’s Mane Mushroom has a long term place throughout Asian traditional medicine, offering incredible anti-inflammation and neuroprotective properties (Beshara et al., 2019). A recent study showed the nootropic’s powerful effects on macrophages (Mori et al., 2015). These are large cells which lie stagnant in tissues at the site of infection or inflammation flare up. Other studies have outlined the mushroom’s ability to relieve oxidative stress and inflammations which contribute to the pathogenesis of neurodegenerative conditions (Kushairi et al., 2019).
Lonvida Curcumin (Turmeric) is a very popular plant in India and Southern Asia for its powerful medicinal properties (Chevallier, 2016). The herb is very popular for its ability to reduce inflammation and reduce symptoms in arthritis patients (Gupte et al., 2019). In fact, long-term use of Turmeric can lead to general pain relief in arthritis patients (Chevallier, 2016). It can be used to treat allergies, asthma, and even eczema. It has even been suggested to have the power to reduce the risk of stroke and heart attack (2016).
Milk Thistle is commonly used medicinally in traditional cultures for its potent seed constituent, silymarin (Chevallier, 2016). There are studies which show the flavonoid silymarin can reduce inflammation (Ashraf et al., 2019). It has also been suggested to offer a reduction of hay fever and allergy symptoms (Bakhshaee et al., 2011).
Nigella Sativa may be a member of the buttercup family, but it is well-known for its potent medicinal applications (Orr, 2014). Nigella (also known as Kalanji or Black Cumin) is popular for its anti-inflammation properties (Chevallier, 2016). In fact, in the Middle East and India it is one of the most popular anti-inflammatory herbs, even being used to treat infection (Orr, 2014). The seeds are commonly used to treat headache, migraine, and even toothaches (Chevallier, 2016). There are studies which outline the nootropic’s ability to treat headaches of all types (Shakeri et al., 2016). It can even improve intestinal barrier function (2016).
Rhodiola, the “Golden Root,” is known throughout many traditional cultures as a powerful, general tonic herb (Orr, 2014). It is used to treat muscle damage, improve the immune system, and for its general anti-inflammatory properties (Beshara et al., 2019).
Tongkat Ali is a potent nootropic supplement most popular in Indochina and Indonesia, being hailed as a versatile tonic and general health herb (Rehman et al., 2016). It can be used as a topical analgesic and as an antibiotic. It has extremely powerful fever-reducing properties (2016). It is also popular for its potent anti-inflammatory properties, even being able to offer pain relief (Han et al., 2016). This is largely due to its ability to inactivate NF-kB signaling pathways (2016).
Last Notes On Using Anti-Inflammation Nootropic Supplements
Finding the right holistic answer for inflammation can require some basic trial and error; however, it is reasonably simple to find a nootropic combination which would help. Some people suffering from severe arthritis or inflammation may choose to make use of multiple nootropic supplements, while others find one is enough to reduce their suffering and improve their pain. The nootropics on this list work great together, not only for inflammation, but in providing other, life-enhancing benefits as well.
A Note From NooFiles
This article is intended to be used for information only. We want to remind you that consulting your physician is recommended before adding any dietary supplement of any kind to your daily regimen.
Ashraf, A., Mahmoud, P., Reda, H., Mansour, S., Helal, M., Michel, H., and Nasr, M. (2019). Silymarin and silymarin nanoparticles guard against chronic unpredictable mild stress induced depressive-like behavior in mice: involvement of neurogenesis and NLRP3 inflammasome. Journal of Psychopharmacology. Vol. 33(5). Pp. 615–631. DOI: https://doi.org/10.1177/0269881119836221
Bakhshaee, M., et al. (2011). Effect of Silymarin in the Treatment of Allergic Rhinitis. Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 145(9). Pp. 904. DOI: 10.1177/0194599811423504
Beshara, J., Engle, D., and Haynes, K. (2019). Beyond Coffee. Monocle Publishing. ISBN 9781544505459
Chang, H., Yang, C., Lu, T., Chang, Y., Peng, W., Huang, S., and Huang, G. (2011). Analgesic Effects and the Mechanisms of Anti-Inflammation of Hispolon in Mice. Evid Based Complement Alternat Med. PMID: 19349477 DOI: 10.1093/ecam/nep027
Chen W, Tan H, Liu Q, Zheng X, Zhang H, Liu Y, and Xu L. (2019). A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus. Molecules. Vol. 24(10). Pp. 1888. DOI: https://doi.org/10.3390/molecules24101888
Chevallier, A. (2016). Encyclopedia of Herbal Medicine. Third Edition. DK Publishing. New York, New York. ISBN 978-1-4654-4981-8
Gupte, P., Giramkar, S., Harke, S., Kulkarni, S., Deshmukh, A., Hingorani, L., Mahajan, M., and Bhalerao, S. (2019). Evaluation of the efficacy and safety of Capsule Longvida® Optimized Curcumin (solid lipid curcumin particles) in knee osteoarthritis: a pilot clinical study. Journal of inflammation research. Vol. 12. Pp. 145–152. DOI: https://doi.org/10.2147/JIR.S205390
Han, Y., Woo, S., Choi, M., Park, Y., Kim, S., Yim, H., and Yoo, H. (2016). Anti inflammatory and analgesic effects of Eurycoma longifolia extracts. Arch Pharm Res. Vol. 39(3). Pp. 421-8. DOI: 10.1007/s12272-016-0711-2
Kaur, S., Sharma, N., Nehru, B. (2018). Anti-inflammatory effects of Ginkgo biloba extract against trimethyltin-induced hippocampal neuronal injury. Inflammopharmacology. Vol. 26(1). Pp. 87-104. DOI: 10.1007/s10787-017-0396-2
Kushairi, N., Phan, C., Sabaratnam, V., David, P., and Naidu, M. (2019). Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia. Antioxidants. Vol. 8. Pp. 261. DOI: https://doi.org/10.3390/antiox8080261
Mori, K., Ouchi, K., and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. Int J Med Mushrooms. Vol. 17(7). Pp. 609-18. DOI: 10.1615/intjmedmushrooms.v17.i7.10
Qian, Z. M., & Ke, Y. (2014). Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer’s Disease?. Frontiers in aging neuroscience, 6, 216. https://doi.org/10.3389/fnagi.2014.00216
Orr, S. (2014). The New American Herbal. Clarkson Potter Publishers. New York, New York. ISBN 978-0-449-81993-7
Osińska-Jaroszuk, M., Sulej, J., Jaszek, M., and Jaroszuk-Ściseł, J. (2020). Applications of Fungal Polysaccharides. Reference Module in Life Sciences. Elsevier. ISBN 9780128096338. DOI: https://doi.org/10.1016/B978-0-12-809633-8.21092-3
Rehman, S. U., Choe, K., and Yoo, H. H. (2016). Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology. Molecules (Basel, Switzerland), Vol. 21(3). Pp. 331. DOI: https://doi.org/10.3390/molecules21030331
Shakeri, F., Gholamnezhad, Z., Mégarbane, B., Rezaee, R., and Boskabady, M. H. (2016). Gastrointestinal effects of Nigella sativa and its main constituent, thymoquinone: a review. Avicenna journal of phytomedicine. Vol. 6(1). Pp. 9–20. PMID: 27247918
Skolnick A. A. (1997). Old Chinese herbal medicine used for fever yields possible new Alzheimer disease therapy. JAMA 277, 776.10.1001/jama.1997.03540340010004
Uskoković, A., Jovanović, J., Dinić, S., Vidaković, M., Mihailović, M., Poznanović, G., and Grdović, N. (2020). Chapter 13 – Mushroom and plant extracts as potential intervention supplements in diabetes management. Biodiversity and Biomedicine. Academic Press. Pp. 247-256. ISBN 9780128195413. DOI: https://doi.org/10.1016/B978-0-12-819541-3.00013-X
Wang, Z., Wang, J., Zhang, H., and Tang, X. (2008). Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia. J Neurochem. Vol. 106(4). Pp.1594-603. DOI: 10.1111/j.1471-4159.2008.05504.x
Wang, J., Zhang, H.Y. and Tang, X.C. (2010), Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J. Neurosci. Res. Vol. 88. Pp. 807-815. DOI: https://doi.org/10.1002/jnr.22237 Zangara, A. (2003). The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer’s disease. Pharmacology Biochemistry and Behavior. Vol. 75(3). Pp. 675-686. DOI: https://doi.org/10.1016/S0091-3057(03)00111-4