Best Nootropics for Immune System Support

Nootropic Supplements used for Immune Support

The immune system is always something worth looking after and strengthening.  Unfortunately, however, it can be argued that it is full of vulnerabilities.  The good news is that with the proper immune support, the system can be significantly bolstered (Alpert, 2017). And there are many nootropics which can be added to almost any nootropic stack to improve and bolster immune system support.

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Top Nootropic Supplements for Immune System

Of the many nootropics which offer immune support benefits, these are the top nootropic supplements used around the world for their ability to boost the immune system.


Ashwagandha assists the body with natural rejuvenation, strength, and overall vitality (Chandrasekhar et al., 2021).  For these reasons it is no surprise it can also help aid the body’s ability to recover and protect itself against germs, viruses, and illness (2021).  There are many studies which offer rock-solid evidence that Ashwagandha provides awesome boosts to the immune system’s function, including enhanced modulation and stimulation (Balch, 2010). And while it is most found in Ayurvedic medicine for its immune system enhancements, more modern, Western studies are beginning to back the herb as a wildly capable supplement in terms of overall vitality (Ziauddin et al., 1995).

Poria Mushroom

Many Asian cultures have long used Poria Mushroom for its ability to modulate the immune system (Sun, 2014).  This means the mushroom purportedly has the ability to offer favorable benefits to the immune system. In fact, one study has suggested that it can significantly improve immune function (Cuellar et al., 1997). It can also help improve symtoms of and reduce the likelihood of developing diabetes (Li et al., 2019).

Red Reishi Mushroom

Red Reishi Mushrooms

Red Reishi Mushroom is commonly used for its immune system-boosting properties (Geng et al., 2017). Its many bioactive components make it an excellent addition to many immune support nootropic stacks (2017). Some studies suggest It can help remove blockages and pressure in the bladder (Paterson, 2006). It can even purportedly be used to control blood sugar (Winska et al., 2019).

Last Words On Using Nootropics for Immune Support

The immune system may seem like a passive, background operation in the body, but it is arguably one of the most important systems of them all! For this reason, it deserves the same, if not more, attention than any of the other major systems in the body.  The nootropic supplements on this list have been proven to assist, whether subtly or in a more profound manner. And many nootropic stacks commonly include at least one immune system booster.

A Note From NooFiles

This article is intended to be used for information only.  We want to remind you that consulting your physician is recommended before adding any dietary supplement of any kind to your daily regimen.


Alpert, P., (2017). The Role of Vitamins and Minerals on the Immune System Home Health Care Management & Practice. DOI:

Balch, P. (2010). Prescription for Nutritional Healing. Fifth Edition. Avery Publishing. New York, New York. ISBN 978-1-58333-400-3

Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255–262.

Geng, P., Siu, K. C., Wang, Z., and Wu, J. Y. (2017). Antifatigue Functions and Mechanisms of Edible and Medicinal Mushrooms. BioMed research international. Vol-Ref: 9648496. DOI:

Li, X., He, Y., Zeng, P., Liu, Y., Zhang, M., Hao, C., Wang, H., Lv, Z., & Zhang, L. (2019). Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China. Journal of cellular and molecular medicine. Vol. 23(1). Pp. 4–20. DOI:

Paterson, R., (2006). Ganoderma – A therapeutic fungal biofactory. Phytochemistry. Vol. 67(18). Pp. 1985-2001. DOI:

Sun, Y. (2014). Biological activities and potential health benefits of polysaccharides from Poria cocos and their derivatives. Int J Biol Macromol. Vol. 68. Pp. 131-4. DOI: 10.1016/j.ijbiomac.2014.04.010

Wińska, K., Mączka, W., Gabryelska, K., & Grabarczyk, M. (2019). Mushrooms of the Genus Ganoderma Used to Treat Diabetes and Insulin Resistance. Molecules (Basel, Switzerland), 24(22), 4075. Ziauddin, M., Phansalkar, N., Patki, P., Diwanay, S., and Patwardhan, B. (1995). Studies on the immunomodulatory effects of Ashwagandha. Journal of Ethnopharmacology. Vol. 50. Pp. 69-76. DOI: 0378-8741/96$15.00

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