Is Caffeine a Nootropic?

Is Caffeine Considered a Nootropic?

What is Caffeine?

CoffeeCaffeine is defined as a substance that works in the body as a central nervous system stimulant. It is a part of the methylxanthine class and it is one of the most popular drugs on the face of the planet. It alters mood, behavior, mental awareness, and even thinking.  The way it works is by blocking the action of adenosine on its receptors; subsequently, this prevents the body from becoming drowsy.  Caffeine is in a lot of supplements, especially when it comes to smart drugs and smart pills.  It can be found in energy drinks, teas, sodas, pills, and seemingly hundreds of other products and supplements.  It is a common ingredient in many nootropic stacks. Especially nootropic stacks which focus on memory, cognitive function, energy, or overall mental acuity.

That said, to determine if caffeine is a nootropic, we must first start by identifying the properties of a nootropic, and whether caffeine fits the bill!

What is a Nootropic?

In modern times, the word “nootropic” has become synonymous with the term “smart drug.” Nootropics have become very popular lately, especially among Western culture.  Nootropics can be classified in three categories including prescription drugs, synthetic substances, and dietary supplements.

The actual term “nootropic” was first coined in 1960s from the latin terms “noos” and “tropein” (which mean mind and bend, respectively) by the Romanian scientist Corneliu E. Giurgea. Nootropics are typically defined as substances which purportedly improve cognitive function with little to no side effects. These cognitive function facets include executive function, attention span, memory, creativity, energy, and motivation. In short, these drugs or supplements typically aim to enhance the function of the mind and body.

Giurgea’s five criteria for a substance being a nootropic include:

  • It must aid or improve working memory or learning in some way
  • It should support brain function under hypoxic conditions
  • It should protect the brain from physical or chemical toxicity in some way
  • It must enhance natural cognitive function
  • It must be non-toxic to humans.

These criteria help determine if a substance is a nootropic or not, and reconfirm that caffeine is not a nootropic for multiple reasons; however, this does not mean that caffeine cannot provide nootropic effects.

Is Caffeine a Nootropic?

In short: Not exactly, caffeine is not considered a nootropic. But there are definitely some nootropic effects which caffeine provides.  Thus, there are also different values in the types of caffeine we consume, and some caffeine is going to be better for the body and offer better effects than others. To clarify: not all types of caffeine are made equal. And those types which are natural, are additionally unequal, as they contain varying amounts (and strengths) of caffeine.

Important note: While caffeine may offer some nootropic benefits, no studies have proven that caffeine can improve memory directly by itself.  Additionally, no studies exist which can prove caffeine offers any neuroprotective advantages.

How Much Caffeine is Too Much?

Coffee at WorkWith that all said, the average person consumes between 50 and 90 mg of caffeine per day. This is not hard to accomplish considering the average cup of coffee contains about 70 to 130 mg of caffeine. Ironically, most people have their coffee in the morning, despite the fact it would be arguably more beneficial in the late morning or early afternoon.  This is because it can battle the effects of the adenosine building up in the system throughout the day (something we will get into later in this article), but is still early enough to allow the effects of caffeine to wear off before bedtime.  Remember, caffeine can last up to twelve hours in the system!

But before we go any further, let’s define the term nootropic, and explain a bit more about what it means for a substance to be a nootropic.

Nootropic Effects of Caffeine

The effects of caffeine will range from person to person, including both intensity and duration.  Generally, caffeine will offer increased mental alertness, physical energy, and enhanced memory and cognitive function.

Caffeine is an easily absorbable nootropic in the body.  Normally, the effects of caffeine are felt between 10 and 30 minutes of ingestion.  It can be faster when caffeine is consumed as a supplement or a nootropic stack.

Some of the negative effects of too much caffeine (especially synthetic caffeine) can include increased breathing, increased heartrate, headaches, and even a heavy crash. This is why it is important to consume proper doses of healthy caffeine only.

How Caffeine Actually Works in the Body

Working In BodyAs previously mentioned, caffeine works by inhibiting the process normally allowed through adenosine.  It literally binds to the adenosine receptors in its place, ensuring that the cell maintains its normal productivity and cannot slow down.  It even speeds up some of the processes produced by these receptors. Basically, caffeine is an adenosine receptor antagonist.

Adenosine itself is a neurotransmitter that creates a natural balance and serenity in the brain, encouraging relaxation and promoting drowsiness. As the day moves forward, more and more adenosine builds up, which explains why people generally become more tired later in the day. Essentially, adenosine works like a messenger in the brain, binding to nerve cell receptors and making the brain feel tired.

Caffeine has been known to improve mood by encouraging the production of dopamine in the system. Dopamine is a neurotransmitter as well and is responsible for mood. It also influences behavior.

It is also noteworthy that caffeine can constrict blood vessels in the brain, which is why caffeine often solves a headache rather quickly. Still, too much caffeine can also promote a headache, thus it should always be consumed in responsible, healthy doses.  Unfortunately, too much caffeine can also cause muscle tension, which can become unpleasant when experienced from heavier doses of caffeine.

Larger doses of caffeine typically create an effect known as the “jitters,” which may last a long while depending upon the amount of the overdose. Jitters can be accompanied by headache, shakiness, and even nausea.

Difference Between Synthetic Caffeine and Natural Caffeine

There are two primary forms of caffeine: synthetic caffeine and natural caffeine. Synthetic caffeine is typically found in energy drinks, sodas, and a variety of supplements (including many smart drugs on the market).  Natural caffeine is metabolized from natural herbs and plants and is not created by man.  This caffeine is arguably far better for the body, as it was intended to be metabolized naturally from the consumption of the plants it is found within.

To summarize: allowing natural caffeine to metabolize in the body via supplement or food gives the body a chance to work it into the system in a non-aggressive, purer fashion, whereas synthetic caffeine often provides too much of a boost all at once.

List of Plants Containing Caffeine

Many examples of plants that contain caffeine could be cited, but some of the strongest include green tea (and all tea), guarana, the coffee plant, cola tree, cacao tree, and yerba mate. The best nootropic supplements will make use of the natural caffeine that is metabolized from these plants. For example, Piratall utilizes a potent green tea extract that gives the body the energy boost and focus it needs, without any of the negative side effects of synthetic caffeine, including crash.

Should All Nootropic Stacks Include Caffeine?

Coffee PlantNot all nootropic stacks require caffeine to be effective. Some nootropic stacks only focus on the production of memory for example, and there are plenty of nootropic plants which offer memory-enhancing effects without the use of caffeine. But for those stronger, cognitive enhancers, some form of caffeine is almost always included. This is because caffeine can be an excellent aid to the effects other nootropics provide.

That all said, there is definitely a use for caffeine within nootropic stacks and supplements, and it can go a long way in contributing to the boost to mental acuity, memory, and energy that is sought after by taking these supplements. If the goal of the supplement has anything to do with cognitive enhancement, it is almost always suggestable that there is some source of caffeine within the supplement.

Final Words on Caffeine as a Nootropic

All-in-all, caffeine is most certainly not a nootropic; however, it possesses many nootropic properties, and it offers many nootropic effects. It is included in many nootropic stacks for these reasons. But with that said, there is also most certainly a difference between synthetic caffeine and natural caffeine, and natural caffeine is the clear winner. It provides a lot of the stimulating, brain-enhancing effects without the side effects and crash.  This is why our products only contain natural sources of caffeine, allowing the body to retrieve the nootropic benefits without any negative effects.  Natural caffeine is by far a very valuable constituent of successful nootropic stacks, especially smart pills like Piratall.

Disclaimer: These statements have not been approved by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease. This article is meant for educational purposes only and should be considered explanatory of the research the author has conducted.

The Nootropics Library: L-Theanine

Everything You Need to Know About L-Theanine and Camellia sinensis

General Information

Scientific Name: [L-Theanine: r-glutamylethylamide, Suntheanin] [Camellia sinensis – the Plant Containing L-Theanine; of the Theaceae Family]

Any Other Names: Theanine, Constituent of Camellia sinensis, Green Tea

Primary Constituents: L-Theanine

Country or Region of Origin: East Asia and Southwestern China

Known Uses: Reduce Stress and Anxiety, Lowers Elevated Blood Pressure, Increases Concentration and Focus, Promotes Relaxation

General History & Introduction

Camellia sinensis is better known as “tea” and is the second highest consumed beverage on the planet (Twilley & Lall, 2018). The Camellia sinensis plant grows as an evergreen shrub around 3-5 feet tall with dark, rough leaves and sweet-smelling, white flowers (Chevallier, 2016).  It is typically found in India, China, and Sri Lanka, where it has established itself as a staple herbal tea even in the earliest of cultures. There are a lot of ancient, cultural rituals in many Asian countries surrounding the drinking of the herbal tea (2016). Each tea plant produces enough leaves to be picked up to 4 times within a year (Shivashankara et al., 2014).

Camellia sinensis also has a long history of use in Ayurvedic medicine (Chevallier, 2016). It has also been well-accepted throughout Indian culture as an herbal tea (2016). And although Camellia sinensis has a lot of great benefits, one of its amino acid derivatives, L-Theanine, is primarily responsible for the plant’s nootropic effects (2016). L-Theanine is well known for its favorable effects on cognitive performance, emotional state and mood, sleep, and a variety of other health benefits (Türközü & Şanlier, 2017).

Important Note: L-Theanine is a derivative of Camellia Sinensis, which is commonly used to make green tea. Both L-Theanine and Camellia Sinensis offer profound cognitive and relaxation effects, only L-Theanine is considered a nootropic and Camellia Sinensis is usually only consumed as a tea. This article will reveal the positive benefits of items, and how their effects may compare and contrast.

Nootropic Benefits of L-Theanine and Camellia sinensis

Concentration, Focus, and Cognitive Benefits (both L-Theanine and Camellia sinensis)

L-Theanine has always been used for its cognitive performance enhancing capability, however, modern studies have begun to record its significant effect on measurable attributes.  For example, one study has measured the chemical’s effects on concentration and learning ability with encouraging results and future propositions for improving the chemical’s value in the brain (Vuong et al., 2011). The nootropic possesses an innate ability to increase cerebral blood flow, especially when it is used alongside caffeine (Dodd et al., 2015). This contribution to brain health is one of the main factors in its reported cognitive benefits (Dodd et al., 2015).


The nootropic provides the brain with increased subjective alertness and improved cognitive function (Giesbrecht et al., 2010). It is one of the primary nootropics benefiting from use alongside another.  In other words: L-Theanine works better when it is used with Caffeine. For example, one study on the combination of L-Theanine and Caffeine found participants to have significantly improved focus and attention-spans during a “demanding cognitive task” (2010).

Reduces Stress and Anxiety, Promotes Relaxation (both L-Theanine and Camellia sinensis)

L-Theanine has been revered throughout Eastern cultures for thousands of years for its ability to reduce oxidative stress and provide focused, calming effects (Ross, 2014). These antioxidant properties are present when the plant is brewed in tea form, as well as within L-Theanine supplements (Chevallier, 2016). There are studies which have shown the primary constituent has a significant positive effect on behavior and mood (Dodd et al., 2015).

One recent, randomized, controlled-trial suggested that L-Theanine can significantly relieves stress-related ailments and promotes overall mental health (Hidese et al., 2019). And some studies suggest that L-Theanine can increase certain neurotransmitters in the brain, which are responsible for promoting relaxation and regulating mood (Nathan et al., 2006). These neurotransmitters include dopamine, serotonin, and GABA (2006).

Digestive Treatments (both L-Theanine and Camellia sinensis)

Gut Flora are microorganisms (bacteria) which live in the intestines and aide in digestion activities. Some recent research suggests that L-Theanine may have the potential to improve Gut Flora in the digestive tract while also limiting the growth and spread of harmful bacteria (Saeed et al., 2019).  It is purportedly also able to reduce risks of infections within digestive organs (Li et al., 2016).  Some research even suggests the chemical can entirely prevent some digestive disorders (Wang et al., 2012).

One study has suggested that drinking unfractionated green tea can help prevent gastrointestinal disorders (Koo & Cho, 2004). More recent research has revealed the polysaccharides from Camellia sinensis flowers are able to regulate gut health (Chen et al., 2019). This same study suggested that the plant also ameliorated cyclophosphamide-induced immunosuppression (2019).

Other Benefits (both L-Theanine and Camellia sinensis)


Camellia sinensis herbal tea has long been used to treat a variety of skin and inflammation conditions (Chevallier, 2016).  It also offers many anti-bacterial benefits. The constituent L-Theanine is great for regulating and improving the quality of sleep (Türközü & Şanlier, 2017). It has also been proven to have positive effects on cancer, cardiovascular disease, and obesity.  The nootropic can even reduce the symptoms of the common cold (2017). Some research has shown that regular consumption of Camellia sinensis can reduce risk of pancreatic cancer (Wang et al., 2012).  Similarly, L-Theanine has been shown to have the potential to prevent and manage many different types of cancers (2012).

And one study revealed L-Theanine’s potential to improve immune function (Li et al., 2016). The chemical has been shown to possess an ability to improve nutrient absorption in the gut (Yan et al., 2017). Vitamins and minerals are literally absorbed better with L-Theanine, improving overall health (2017).

Dosing and Usage Information

Normally, only the leaves and buds of the Camellia sinensis plant are used, and this includes in the extraction of primary constituent, L-Theanine (Chevallier, 2016). Dietary supplements typically contain a maximum of 400 mg of L-Theanine extract.

Side Effects

Although more research is still required to draw ultimate consensus, one recent study on the safety and effects of using L-Theanine on a regular basis revealed the chemical as reliable and generally accepted as safe, even when consumed in larger quantities (Türközü & Şanlier, 2017). That said, while uncommon, some side effects may include headaches, irritability, and nausea (Giesbrecht et al., 2010).

Other Important Information

Sometimes Camellia sinensis is mixed with other herbs to create intricate herbal tea concoctions.  Cinnamon is one of the most popular additives (Chevallier, 2016).  The plant is used to produce all kinds of teas, including the traditional black, oolong, and green teas (Shivashankara et al., 2014).

The primary constituent responsible for the nootropic benefits of the tea, L-theanine, is also responsible for the flavorful taste of the tea (Vuong et al., 2011).


L-Theanine and its parent plant, Camellia sinensis, are extremely effective brain-boosters and have been well-known throughout many cultures as such.  They also offer relaxation-inducing effects.  L-Theanine’s nootropic benefits are constantly being investigated and backed by a growing archive of studies and empirical data. For this reason, L-Theanine has become one of the more popular nootropics, especially in Western cultures. And its effects on cognitive function and stress make it a great addition to most nootropic stacks.

A Note from NooFiles

This article is intended to be used for information only.  We want to remind you that consulting your physician is recommended before adding any dietary supplement of any kind to your daily regimen.


Chen, D., Chen, G., Ding, Y., Wan, P., Peng, Y., Chen, C., Ye, H.,, Zeng, X., and Ran, L. (2019). Polysaccharides from the flowers of tea (Camellia sinensis L.) modulate gut health and ameliorate cyclophosphamide-induced immunosuppression. Journal of Functional Foods. Vol. 61. DOI:

Chevallier, A. (2016). Encyclopedia of Herbal Medicine. Third Edition. DK Publishing. New York, New York. ISBN 978-1-4654-4981-8

Dodd, F., Kennedy, D., Riby, L., and Haskell-Ramsay, C. (2015). A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood. Psychopharmacology (Berl). Vol. 232(14). Pp. 2563-76. DOI: 10.1007/s00213-015-3895-0

Giesbrecht, T., Rycroft, J., Rowson, M., and De Bruin, E. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci. Vol. 13(6). Pp. 283-90. DOI: 10.1179/147683010X12611460764840

Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., and Kunugi, H. (2019). Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. Vol. 11(10). Pp. 2362. DOI: 10.3390/nu11102362

Koo, M., and Cho, C. (2004). Pharmacological effects of green tea on the gastrointestinal system. Eur J Pharmacol. Vol. 500(1-3). Pp. 177-85. DOI: 10.1016/j.ejphar.2004.07.023

Ross, S. (2014). L-theanine (suntheanin): effects of L-theanine, an amino acid derived from Camellia sinensis (green tea), on stress response parameters. Holist Nurs Pract. Vol. 28(1). Pp. 65-8. DOI: 10.1097/HNP.0000000000000009

Saeed, M., Yatao, X., Tiantian, Z., Qian, R., and Chao, S. (2019). 16S ribosomal RNA sequencing reveals a modulation of intestinal microbiome and immune response by dietary L-theanine supplementation in broiler chickens. Poult Sci. Vol. 98(2). Pp. 842-854. DOI: 10.3382/ps/pey394

Li, C., Tong, H., Yan, Q., Tang, S., Han, X., Xiao, W., and Tan, Z. (2016). L-Theanine Improves Immunity by Altering TH2/TH1 Cytokine Balance, Brain Neurotransmitters, and Expression of Phospholipase C in Rat Hearts. Medical science monitor : international medical journal of experimental and clinical research. Vol. 22. Pp. 662–669. DOI:

Nathan, P., Lu, K., Gray, M., and Oliver, C., (2006). The Neuropharmacology of L-Theanine(N-Ethyl-LGlutamine). Journal of Herbal Pharmacotherpay. Vol. 6(2). Pp. 21-30. DOI: 10.1080/J157v06n02_02

Shivashankara, A., and Baliga, M. (2014). Polyphenols in Chronic Diseases and their Mechanisms of Action Polyphenols in Human Health and Disease. Academic Press. ISBN: 978-0-12-398456-2. DOI:

Türközü D., and Şanlier, N. (2017).  L-theanine, unique amino acid of tea, and its metabolism, health effects, and safety. Crit Rev Food Sci Nutr. Vol. 57(8). Pp. 1681-1687. DOI: 10.1080/10408398.2015.1016141

Twilley, D., and Lall, N. (2018). Are Medicinal Plants Effective for Skin Cancer? Medicinal Plants for Holistic Health and Well-Being. Academic Press. ISBN: 978-0-12-812475-8. DOI:

Vuong, Q., Bowyer, M., and Roach, P. (2011). L-Theanine: properties, synthesis and isolation from tea. J Sci Food Agric. Vol. 91(11). Pp. 1931-9. DOI: 10.1002/jsfa.4373

Wang, J., Zhang, W., Sun, L., Yu, H., Ni, Q., Risch, H., and Gao, Y. (2012). Green tea drinking and risk of pancreatic cancer: A large-scale, population-based case–control study in urban Shanghai. Cancer Epidemiology. Vol. 36(6). Pp. e354-e358 DOI:

Yan, Q., Tong, H., Tang, S., Tan, Z., Han, X., and Zhou, C. (2017). L-Theanine Administration Modulates the Absorption of Dietary Nutrients and Expression of Transporters and Receptors in the Intestinal Mucosa of Rats. BioMed research international. DOI: