Nootropics that Help with Mental Acuity and Cognitive Performance

Best Nootropics for Cognitive Function and Mental Acuity

Nootropics are generally well-known for their ability to enhance the mind and improve cognitive function.  Nootropics are sometimes considered the “authentic” limitless pill.  Some of the nootropics on this list have been used for thousands of years for their ability to sharpen thinking, improve memory, and enhance overall cognitive performance.  Some of them are even backed by several clinical trials and studies for their mental-enhancing abilities, including improving fluid intellect.  For some individuals, just one cognitive enhancing nootropic is enough, while others may compose an entire nootropic stack, utilizing many of the nootropics on this list.

Top 15 Nootropics for Mental Acuity

Of the many nootropics for mental acuity, these are the highest functioning cognitive supporters available throughout Eastern and Western culture.

Ashwagandha

Ashwagandha is a powerful cognitive enhancing nootropic.  The herb is well-known to improve overall brain function and maximize one’s learning potential and memory (Orr, 2014). The ability of the herb to improve general vitality, energy, and vigor, greatly contributes to its cognitive-enhancing properties (Choudhary et al., 2017).  Many studies exist which showcase the herb’s ability to boost mental acuity, however, one recent, double-blind, placebo-controlled study in particular outlined its significant bolster to many cognitive functions (2017). It is also commonly used to improve facets of cognitive dysfunction (Ng et al., 2020). It is even prescribed as a treatment for individuals suffering from Alzheimer’s disease and numerous forms of dementia (2020).

Bacopa Monnieri

Bacopa is one of the most versatile nootropics for cognitive function. The herb is commonly turned to for its brain-boosting benefits, including improvements to executive functioning, memory, concentration, learning, and more (Chevallier, 2016).  It has been proven to reduce leanring time and increase memory recall (2016). Bacopa is found prominently used throughout Ayurvedic medicine, especially for brain-oriented conditions and benefits (Orr, 2014). Recent studies have proven the herb useful for increasing memory recall, memory storage, processing speed, and learning rate (Beshara et al., 2019). There are even studies which suggest it has the ability to improve cerebral blood flow (Aguiar & Borowski, 2013).

Black Hoof Mushroom

Black hoof Mushroom is very commonly utilized in Ancient Chinese culture and modern Chinese medicines for its benefits to cognitive performance (Pham-Huy et al., 2008).  Ultimately, this herb is a powerful antioxidant, offering incredible relief to oxidative stress. The mushroom also offers incredible neuroprotective properties, energy that is required by the body, but not necessarily produced by the body (2008).  The polysaccharides the herb contains are the primary and impressive conductors of its antioxidant activities (Wang et al., 2014).  It has even been suggested that Black Hoof Mushroom can help prevent neurodegenerative disease (Choi et al., 2016).

Citicoline

Black Hoof Mushroom

Citicoline is one of the strongest nootropic neuroprotective supplements.  Several studies have proven its ability to improve brain metabolism through the manipulation of numerous neurotransmitters (Secades & Lorenzo, 2006). It has been proven in scientific studies to improve overall cognition (2006). It has also been shown to reduce cognitive impairment and neurodegenerative disorders (Grieb, 2014). The nootropic has been theorized to possess cognitive enhancing properties due to its ability to increase phosphatidylcholine levels in the brain (Conat & Schauss, 2004).  This is because phosphatidycholine is one of the most important brain chemicals responsible for brain function and cognitive performance (2004).

Ginkgo Biloba

Ginkgo is one of the more versatile nootropics, especially when it comes to cognitive enhancements.  Not only is it an antioxidant, giving the brain a better opportunity to relax and think, it also has been purported to increase blood flow to the brain (Balch, 2010). It has been suggested as a treatment for Alzheimer’s and other neurodegenerative diseases (Chevallier, 2016).  The herb has thousands of years of history being used as a neuroprotective, cognitive enhancer; and its ability to improve cerebral blood flow contributes to its memory-boosting properties too (2016). In fact, multiple recent studies have outlined Ginkgo’s ability to improve both short and long-term memories (Balch, 2010).  Additional studies outline its ability to improve the peripheral circulation system, thus promoting overall cognitive function (2016).

Gotu Kola

Gotu Kola has a lengthy history as a cognitive enhancing nootropic, dating back thousands of years (Gohil et al., 2010).  The herb has been backed by many modern studies which showcase its ability to improve memory and brain function (Farhana et al., 2016).  It has been used for treatment of neurodegenerative disorders and memory deficits (Walker & Brown, 1998).  Asian and Ayurvedic medicines alike have turned to the plant for concentration boosts and increases to attention span (Farhana et al., 2016).  Ultimately, it is one of the most powerful herbs for alertness and maximizing cognitive performance (Orr, 2014).

Huperzine A

Huperzine A

One of the most popular and effective nootropics for enhancing cognitive performance is Huperzine A. While it has had a strong history of use for its cognitive enhancing benefits throughout Chinese culture, it has been recently adopted in Western medicine and cultures as well (Walker & Brown, 1998).  The herb has served as a supplement, as well as in herbal tea form.  It is commonly used throughout the world for its memory and mental capacity-increasing potential (1998). Most of its brain-boosting benefits can be attributed to its ability to ass the blood-brain barrier (Zangara, 2003).  It also offers incredible neuroprotective benefits (2003).

Lemon Balm

As a natural nervous system relaxant (Chevallier, 2016), it is no wonder Lemon Balm can help the mind can achieve its full potential. The herb’s antioxidant properties help reduce oxidative stress and give the brain a chance to completely perform (Rafieian-Kopaei et al., 2017).  Ultimately, the herb has been a primary staple in many traditional holistic practices for its cognitive support properties (Aubert et al., 2019).  There are even clinical trials which suggest enhanced cognitive performance (Shakeri et al., 2016). Most of its mental energy-boosting properties and attention benefits come from the herb’s potent polyphenol content (Scholey & Stough, 2011).

Lion’s Mane Mushroom

Lion’s Mane Mushroom has an innate ability to reduce depression and increase the brain’s potential for a balanced, peaceful function (Beshara et al., 2019).  The mushroom can increase cognitive function, decrease some cognitive impairment, improve memory, and boost attention-span (Nagano et al., 2010). A lot of these abilities come from the herb’s nerve growth factor improvements (Li et al., 2018). Recent studies have been indicating Lion’s Mane’s ability to significantly improve cognitive function scores (Mori et al., 2009). A lot of these benefits purportedly come from the herb’s antioxidant and neuroprotective abilities (Kushairi et al., 2019).

Longvida Curcumin

While Longvida Curcumin has been long used for its ability to relax the body and mind, it has an even longer history being used for its cognitive function and memory-bolstering capabilities (Cox et al., 2015). One recent study outlined the herb’s ability to improve overall cognitive function, attention-span, and working memory tasks (2015). Other studies have proven the herb to be useful in the treatment of dementia and traumatic brain injury (Mishra & Palanivelu, 2008). These same studies showcased the plant’s incredible antioxidant benefits and its ability to improve cognitive function in Alzheimer’s patients (2008).  Other studies have proven Turmeric’s ability to favorably impact working memory (Kuszewski et al., 2018). Some research suggests the herb’s cognitive performance enhancing capabilities stem from its anti-amyloid brain effects (Small et al., 2018).

L-Theanine

L-Theanine is one of the most turned-to nootropics for overall cognitive performance.  This is likely due to its ability to increase cognitive function in several measurable ways. One study covered the nootropic’s benefit to concentration and learning ability (Vuong et al., 2011). Its ability to increase cerebral blood flow is a massive pro, giving the brain the cognitive advantages it needs (Dodd et al., 2015).  Additionally, L-Theanine increases alertness, concentration, attention-span, and focus (Giesbrecht et al., 2010).

L-Tyrosine

L-Tyrosine has the potent ability to improve both cognitive function and memory, especiallyin stressful situations (Young 2007).  It cna increase mental processing skills and replenish cognitive resources on-demand (Colzato et al., 2013).  The nootropic is also helpful in improving working memory (2013). Many studies and empirical trials have outlined the nootropic’s abilities as a powerful cognitive enhancer (McTavish et al., 2005).  One study in particular proved L-Tyrosine has the ability to improve participants’ arithmetic skills, visual and audio monitoring skills, memory tests, and other attributes of cognitive performance (Colzato et al., 2013).

Panax Ginseng

GInseng

Not only is Panax Ginseng commonly used as a natural stimulant (Chevallier, 2016), but it is also well-known around the world for its ability to improve overall cognitive performance (Beshara et al., 2019). The herb has many clinical trials backing its abilities to enhance cognitive function in healthy adults, with many trials suggesting the herb can even help improve Alzheimer’s patients (2019). Some recent Russian studies show the herb to improve mental activity, increase attention-span and alterness, and even enhance the mental value of energy (Balch, 2010).

Poria Mushroom

Although Poria Mushroom might be discussed less often than other nootropics, its ability to improve cognitive function cannot be ignored.  In fact, it has a long history of being utilized as a memory and cognitive boosting nootropic (Lin et al., 2012). It has been suggested to have the ability to increase cerebral blood flow, allowing it to improve working memory and executive function (Sun et al., 2021). Poria Mushroom is often used as a treatment for neurodegenerative diseases and dementia (Lin et al., 2012).  It is even used to enhance memory recall and learning ability (Wu et al., 2020).

Rhodiola Crenulate

Besides the fact that Rhodiola can massively decrease stress and offer the brain a balanced, adaptogenic atmosphere for function, it can also improve overall mental acuity (Orr, 2014).  The herb is well-known for its ability to release mental tension (2014), enhance circulation to the brain, and act as a significant precursor for critical-important cognitive enhancing neurotransmitters (Tabassum et al., 2012). It is frequently combined with Ginkgo Biloba for enhanced mental endurance (Zhang et al., 2009), and is often chosen as one of the most potent nootropics for entrepreneurs (Al-Kuraishy, 2015).

Last Words of Wisdom on Using Nootropics for Cognitive Enhancement

Although there are many nootropics and herbs which can help improve cognitive performance, some clearly perform better than others. The above list encompasses the top 15 nootropics (in alphabetical order) used for improving cognitive enhancement and mental acuity.  Many of them will help improve fluid intelligence, as well as crystallized intelligence.  Taken together, some of these nootropics will even make a great nootropic stack, compounding the mental gains!

A Note From NooFiles

This article is intended to be used for information only.  We want to remind you that consulting your physician is recommended before adding any dietary supplement of any kind to your daily regimen.

Sources

Aguiar, S., & Borowski, T. (2013). Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation research. Vol. 16(4). Pp. 313–326. DOI: https://doi.org/10.1089/rej.2013.1431

Al-Kuraishy H. M. (2015). Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy. Journal of intercultural ethnopharmacology. Vol. 5(1). Pp. 7–13. DOI: https://doi.org/10.5455/jice.20151123043202

Balch, P. (2010). Prescription for Nutritional Healing. Fifth Edition. Avery Publishing. New York, New York. ISBN 978-1-58333-400-3 Beshara, J., Engle, D., and Haynes, K. (2019). Beyond Coffee. Monocle Publishing. ISBN 9781544505459

Chevallier, A. (2016). Encyclopedia of Herbal Medicine. Third Edition. DK Publishing. New York, New York. ISBN 978-1-4654-4981-8

Choi, D., Cho, S., Yeon Seo, J., Burm Lee, H., and Park, Y. (2016). Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells. Nutrition
Research. Vol. 36(1). Pp. 31-43. ISSN 0271-5317. DOI: https://doi.org/10.1016/j.nutres.2015.11.005

Choudhary D., Bhattacharyya S., and Bose S. (2017). Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions. J Diet Suppl. Vol. 14(6). Pp. 599-612. DOI: 10.1080/19390211.2017.1284970

Conant, R. and Schauss, A. (2004). Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature. Alternative Medicine Review. Vol. 9(1). Pp.
17–31. PMID 15005642

Colzato, L., Jongkees, B., Sellaro, R., and Hommel, B. (2013). Working memory reloaded: tyrosine repletes updating in the N-back task. Frontiers in behavioral neuroscience. Vol. 7. Pp. 200. DOI:
https://doi.org/10.3389/fnbeh.2013.00200

Cox, K., Pipingas, A., and Scholey, A. (2015). Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. Vol. 29(5). Pp. 642-51. DOI:
10.1177/0269881114552744

Dodd, F., Kennedy, D., Riby, L., and Haskell-Ramsay, C. (2015). A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral
blood flow, cognition, and mood. Psychopharmacology (Berl). Vol. 232(14). Pp. 2563-76. DOI: 10.1007/s00213-015-3895-0

Farhana, K., Malueka, R., Wibowo, S., & Gofir, A. (2016). Effectiveness of Gotu Kola Extract 750 mg and 1000 mg Compared with Folic Acid 3 mg in Improving Vascular Cognitive Impairment after stroke. Evidence-based complementary and alternative medicine. PMID: 2795915. DOI: https://doi.org/10.1155/2016/2795915

Giesbrecht, T., Rycroft, J., Rowson, M., and De Bruin, E. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci. Vol. 13(6). Pp. 283-90. DOI: 10.1179/147683010X12611460764840

Gohil, K., Patel, J., & Gajjar, A. (2010). Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all. Indian journal of pharmaceutical sciences. Vol. 72(5). Pp. 546–556. DOI:
https://doi.org/10.4103/0250-474X.78519

Grieb P. (2014). Neuroprotective properties of citicoline: facts, doubts and unresolved issues. CNS drugs. Vol. 28(3). Pp. 185–193. DOI: https://doi.org/10.1007/s40263-014-0144-8

Li, I., Lee, L., Tzeng, T., Chen, W., Chen, Y., Shiao, Y., and Chen, C. (2018). Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behavioural neurology. PMID: 29951133. DOI:
https://doi.org/10.1155/2018/5802634

Lin, Z., Gu, J., Xiu, J., Mi, T., Dong, J., and Tiwari, J. K. (2012). Traditional chinese medicine for senile dementia. Evidence-based complementary and alternative medicine. PMID: 21808655. DOI:
https://doi.org/10.1155/2012/692621

Kushairi, N., Phan, C., Sabaratnam, V., David, P., and Naidu, M. (2019). Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation
in HT22 Hippocampal Neurons and BV2 Microglia. Antioxidants. Vol. 8. Pp. 261. DOI: https://doi.org/10.3390/antiox8080261

Kuszewski, J., Wong, R., and Howe, P. (2018). Can Curcumin Counteract Cognitive Decline? Clinical Trial Evidence and Rationale for Combining ω-3 Fatty Acids with Curcumin. Advances in Nutrition. Vol. 9(2). Pp. 105–113, DOI: https://doi.org/10.1093/advances/nmx013

McTavish, S., Mannie, Z., and Harmer, C. (2005). Lack of Effect of Tyrosine Depletion on Mood in Recovered Depressed Women. Neuropsychopharmacol. Vol. 30. Pp. 786–791. DOI: https://doi.org/10.1038/sj.npp.1300665

Mishra, S., & Palanivelu, K. (2008). The effect of curcumin (turmeric) on Alzheimer’s disease: An overview. Annals of Indian Academy of Neurology. Vol. 11(1). Pp. 13–19. DOI:
https://doi.org/10.4103/0972-2327.40220

Mori, K., Inatomi, S., Ouchi, K., Azumi, Y. and Tuchida, T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled
clinical trial. Phytother. Res. Vol. 23. Pp. 367-372. DOI: https://doi.org/10.1002/ptr.2634

Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., and Ohnuki, K. (2010). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. Vol. (4). Pp. 231-7. DOI:
10.2220/biomedres.31.231  Ng, Q., Loke, W., and Foo, N. (2020). A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction. Phytotherapy Research. Vol. 34. Pp. 583– 590.
DOI: https://doi.org/10.1002/ptr.6552

Orr, S. (2014). The New American Herbal. Clarkson Potter Publishers. New York, New York. ISBN 978-0-449-81993-7

Pham-Huy, L. A., He, H., & Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. International journal of biomedical science : IJBS, 4(2), 89–96.

Rafieian-Kopaei, M., and S., K. (2017). Melissa officinalis L: A Review Study With an Antioxidant Prospective. J Evid Based Complementary Altern Med.  Vol. 22(3). Pp. 385-394. DOI:
10.1177/2156587216663433

Scholey, A., and Stough, C. (2011). 11 – Neurocognitive effects of herbal extracts. Behaviour and Psychiatric Illness. In Woodhead Publishing Series in Food Science, Technology and Nutrition, Lifetime
Nutritional Influences on Cognition. Woodhead Publishing. Pp.272-297. ISBN 9781845697525. DOI: https://doi.org/10.1533/9780857092922.2.27

Secades, J. and Lorenzo, J. (2006). Citicoline: pharmacological and clinical review. Methods Find Exp Clin Pharmacol. Suppl Vol. B. Pp. 1-56. PMID: 17171187.

Shakeri, A., Sahebkar, A., and Javadi, B. (2016). Melissa officinalis L. —A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. Vol. 188. Pp. 204–228.

Small, G., Siddarth, P., Li, Z., Miller, K., Ercoli, L., Emerson, N., Martinez, J., Wong, K., Liu, J., Merrill, D., Chen, S., Henning, S., Satyamurthy, N., Huang, S., Heber, D., and Barrio, J. (2018). Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. The American Journal of Geriatric Psychiatry. Vol. 26(3). Pp. 266-277. DOI: https://doi.org/10.1016/j.jagp.2017.10.010

Sun Y, Liu Z, Pi Z, Song F, Wu J, and Liu S. (2021). Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis.
Phytother Res. DOI: 10.1002/ptr.7014

Tabassum, N., Rasool, S., Malik, Z., Ahmad, F. (2012). Natural Cognitive Enhancers. Journal of Pharmacy Research. Vol. 5(1). ISSN: 0974-6943.

Vuong, Q., Bowyer, M., and Roach, P. (2011). L-Theanine: properties, synthesis and isolation from tea. J Sci Food Agric. Vol. 91(11). Pp. 1931-9. DOI: 10.1002/jsfa.4373

Walker, L., and Brown, E. (1998). The Alternative Pharmacy. Prentice Hall Press. Paramus, New Jersey.  ISBN 0-7352-0021-1

Wu, F., Li, S., Dong, C., Dai, Y., and Papp, V. (2020). The Genus Pachyma (Syn. Wolfiporia): Reinstated and Species Clarification of the Cultivated Medicinal Mushroom “Fuling” in China. Frontiers in
Microbiology. Vol. 11. DOI: 10.3389/fmicb.2020.590788

Young S. N. (2007). L-tyrosine to alleviate the effects of stress. Journal of psychiatry & neuroscience.  JPN. Vol. 32(3). Pp. 224. PMID: 17476368

Zangara, A. (2003). The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer’s disease. Pharmacology Biochemistry and Behavior. Vol. 75(3). Pp. 675-686. DOI: https://doi.org/10.1016/S0091-3057(03)00111-4

Zhang, Zj., Tong, Y., and Zou, J. (2009). Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances the endurance performance in healthy volunteers. Chin. J. Integr. Med.
Vol. 15. Pp. 177–183. DOI: https://doi.org/10.1007/s11655-009-0177-x