Best Supplements for Beating Laziness

What Are the Best Supplements for Motivation?

Are There Any Supplements for Laziness?

Modern times have produced a society that relies heavily upon technology, robotics, and all types of automation.  Information and communication is now at the fingertips to the point laziness has begun looming throughout many lives. It can be hard to wake up feeling fresh, uncovering enough motivation to get to work, or finding one’s creativity. Even with careful consideration, a balanced diet, and healthy routines, many people still struggle to attain enough motivation to get out of bed, shower, get dressed, work out, get to their job, or even put on a smile.  The world has become extremely black and white, which can give many people an unfortunate sense of dystopia; However, fear not! There is hope after all!

Fortunately, there are many supplements (namely nootropics) which are specifically used to address laziness and motivation issues.  These nootropic ingredients and supplements can be extremely effective at eliminating fatigue, honing focus, and concentration, and delivering a rejuvenated sense of self.  The best supplements for laziness will help promote ambition, drive, and energy galore!

What Causes Laziness?

Although all people are different, laziness has a few common constituents which can be easily outlined and identified. Laziness can be separated into two categories: (a) a general lack of motivation and unwillingness to do anything, and (b) a temporary nature of lack of desire to do something, also known as “situational laziness” (Maximets, 2019).  This brings us to our first few indicators laziness is present:

  • + Lack of motivation
  • + Unwilling to do anything
  • + Temporary lack of desire to do something specific


Sometimes these indicators might go by different names, such as apathy or inaction.  These calling signs of laziness might be accompanied by other factors such as focusing too much on internal feelings, depression, or even feelings of guilt (2019).  Some other personal determinants of laziness include drowsiness, the need or desire to rest, having no mood, experiencing any poor psychological level of feeling or thinking, and boredom.  Some individuals describe laziness in more disguised terms, such as lack of opportunity, a lack of interest, or experiencing too much external pressure.

There are also several areas of life which may be more prone to inducing or contributing to the development or experience of laziness.  These “life areas” include professional or work activities, educational studies, household chores, or tasks associated with high levels of pressure.  Lacking significant motivation or reward for completing a task will amplify laziness (2019).  Some studies indicate social loafing as a contributing factor to increased laziness within the individual (Ying et al., 2014).  Social loafing is the concept that a person will be more naturally to exert less effort to achieve a goal or objective when working in a group rather than independently (Karau and Williams, 1993).

No matter the cause of laziness, the lack of motivation will result in decreased productivity, decreased success, and ultimately decreased self-esteem and confidence.  The good news is, with the correct practices and behavior, laziness can be resolved, and motivation can ensure!

Finding Your Inner Beast…

Having low energy can have a significant impact on the mind and body.  In turn, it affects outward behavior, interactions with other people, and overall productivity.  Low energy and motivation can create a productivity-less cycle that is extremely hard to overcome.  Negative momentum begins to build which creates a slew of negative habits

Fortunately, it is possible to find and release the inner beast inside!  One of the best ways beyond physical exercise and proper dieting to access the best version of oneself is dietary supplements and nootropic stacks. Some of the strongest nootropic candidates for producing energy include Green Tea Extract, Siberian ginseng, Guarana, Yohimbe, Maca, Rhodiola Rosea, and the Green Coffee Bean. The two major winners here are Green Tea Extract and Siberian ginseng. These two nootropics are especially efficient when used together.

Using Green Tea Extract for Energy

The reason Green Tea Extract is one of the best suited nootropics for energy for two main reasons: (a) it contains the right amount of healthy, natural caffeine, and (b) it includes antioxidant properties.  Antioxidants inhibit oxidation, or the reduction of free radicals in the system.  Free radicals greatly damage cells, so eliminating these types of interactions in the body is imperative for feeling good.  The combination of the antioxidant properties and natural caffeine in Green Tea Extract make it a clear power player in terms of giving the brain its best chance to function optimally.  If this were not enough, Green Tea Extract is known to also help bolster cognitive function and working memory (Schmidt, 2014).

Using Siberian Ginseng for Energy

Siberian Ginseng (Eleutherococcus senticosus) has traditionally been used to create natural energy in the mind and body and improve overall productivity. Many people think all types of Ginseng are the same, however, this is absolutely untrue. Siberian Ginseng is a completely different herb than Panax Ginseng or American Ginseng. Additionally, the quality of Siberian Ginseng can greatly vary from product to product, so it is especially careful to find a high-quality source of the nootropic.  This can be harder when one does not reside directly in the Siberian area.

And remember, these two nootropics will produce the most optimum results when they are used together!

Destroy Fatigue for Good…

Finding oneself in a state of extreme exhaustion can be a heavy contributor to laziness and a lack of productivity. It is also possible to experience chronic laziness because of being chronically fatigued.  When time is spent doing nothing, or being less than productive, potential is far from being achieved.  And one of the first steps in resolving chronic fatigue is clearing the mind of stress and promoting inner relaxation.  Giving the mind a chance to achieve peace means a balanced train of thought, and a balanced train of thought leads to maximizing productivity.

The base idea of the adaptogen is to promote overall homeostasis in the body. Adaptogens are suggested to work in the body by improving attention, reducing overall stress, improving facets of endurance, balance hormone levels, lubricate and stimulate mental performance, and improve many other parts of the body’s functions (Christiansen and Bhatia, 2020).

Some of the most exceptional adaptogens are nootropics.  Nootropics are neuroprotective and naturally enhance the mind and/or body with minimal to no negative effects.  In fact, the best nootropics typically come at no negative effects whatsoever!  Two of the most ideal adaptogen nootropics are Hawthorn and Siberian Ginseng.

Using Hawthorn as an Adaptogen

Hawthorn (Crataegus spp.) is one of the most potent nootropic adaptogens available. It is a therapeutic herb, helping the mind and body to achieve a true state of optimization.  This is done through its ability to relieve stress and promote a healthy cardiovascular system (Tassell et al., 2010). Hawthorn is excellent at giving the body its best opportunity to adapt to environmental and internal stresses.  That is why it is so well-known and used so commonly to treat heart failure (Sherman, 2008).

Using Siberian Ginseng as an Adaptogen


Siberian Ginseng was suggested above as being a big proponent for producing energy in the mind and body; However, it is such a power player nootropic because it also works wonders as an adaptogen.  In fact, it is regularly used to combat chronic fatigue and help the body’s physiological processes achieve homeostasis in cultures around the entire world.  Siberian Ginseng’s traditional use for its natural abilities to promote overall wellness and energy in the body has been used for centuries (Ruper and Maxim, 2017).

Learning to use nootropic adaptogens, such as the two mentioned above, correctly with other nootropics to form an energizing, cognitive-enhancing, and stress relieving stack, is an invaluable skill!

Flex Your Cognitive Muscle…

Many people spend a lot of time working out their physical body, developing fine-tuned muscles they can be proud of and truly count on.  However, many more people seem to overlook fine-tuning and flexing the strength and power of their mind. Similar to how a body lacking exercise will lack strength and physical ambition, a mind lacking attention will lack mental acuity and cognitive vigor.

Nootropics are also well-known for their ability to improve fluid intelligence.  This is a highly motivating facet of these seemingly magic substances, as fluid intelligence means faster processing power and more lubricated cognitive functioning.  Additionally, higher fluid intelligence almost always leads to stronger crystallized intelligence as well, or the formation of more knowledge and wisdom overtime (Brown, 2016). And with some nootropics being able to provide such a strong boost to both fluid intelligence and crystallized memory, it would be silly not to include at least some of them in a nootropic stack.

A series of potent nootropics offer insanely advantageous mental benefits. Some of the best nootropics for promoting cognitive function and memory include Huperzine A, Bacopa monnieri, Guarana, Rhodiola rosea, and L-Theanine.  The two most popular and efficient nootropics on this list are Huperzine a and Bacopa monnieri.

Using Huperzine A to Boost Cognitive Function and Memory…

Huperzine A has long been revered for its contributions to memory and cognitive function. It is one of the strongest nootropics for improving fluid intelligence and crystallized intelligence.  Huperzine is even used to treat several forms mental dementia and deterioration, including Alzheimer’s disease (Zangara, 2003). It has been used for centuries in traditional Chinese medicine and has been well-proven to improve memory (2003).  Like many other quality nootropics, it also offers potent neuroprotective properties.  Huperzine A can help protect neurons from cell death, has excellent blood brain barrier penetration, and discourages the breakdown of acetylcholine (Roberts, 2006). These attributes can massively contribute to improved memory and overall cognitive function.

Using Bacopa Monnieri to Boost Cognitive Function and Memory…

Bacopa monnieri is one of the more popular nootropics in modern times for improving cognitive function and memory; However, it has been well-known throughout ancient times and has a strong place in traditional Ayurvedic medicine (Entity Health Limited, 2018).  As time has advanced, more and more research has become available on the herb and its ability to provide the brain with many benefits.  In fact, there are many studies which absolutely show Bacopa has a significant effect on fluid intelligence, cognitive functions, and overall memory (Pase et al., 2012). Additionally, Bacopa Monnieri offers wonderful antioxidant properties, making it a very healthy nootropic (Simpson et al., 2015).

With the right nootropics supplement of stack, the brain is capable of such greater potential!

What Are Nootropics?

Many people misconstrue nootropics to only be substances which enhance cognitive function; However, the true definition of a nootropic includes a broader arrangement of substances. Technically, nootropics are natural plants or substances which possess most (or all) of these key attributes:

  • + Neuroprotective (or protecting neurons in the brain)
  • + Increases blood flow and/or oxygen to the brain or throughout the body
  • + Promotes improved cognitive or brain functioning (Koshibu, 2016)
  • + Possesses little to no negative side effects


The term nootropic comes from the Greek word “noos” which translates to “mind,” and “trope,” which translates into “to bend.”  The word “nootropic” itself was coined by Dr. Corneliu E. Giugrea, famed Romanian psychologist.  Despite nootropics consisting of a variety of substances, Dr. Giugrea focused a lot of his studies on brain-enhancing compounds.  While some sources consider both synthetic and organic substances nootropics, traditionally only natural substances are considered nootropics.

Nootropic Stacks Really Work!

Although there are literally endless combinations of nootropics, it is certain that some of the most well-developed nootropic stacks and supplements offer invaluable motivation, energy, and focus. There are very balanced supplements which home in on the true constituents of laziness and work to eliminate them.  These supplements develop amazing motivation and encourage maximum productivity. These supplements make it possible to fine tune the brain and amplify the body’s willingness to perform!  Many nootropics have been proven to offer neuroprotective and cognitive-enhancing properties to the ability of even rebuilding neuroarchitecture (Koshibu, 2016).  Several studies exist which directly indicate improved cognitive functioning from various nootropics (Stough et al., 2008).

While research on many nootropics is still rather young, there is enough empirical data (especially within the last decade) revealing several successful nootropic trials.  One of the current focuses in many studies within the industry today, is determining the most optimum doses various nootropics required to pass the blood brain barrier thereby stimulating response mechanisms (Suliman et al., 2016).  It is fortuitous that research and studies are far enough along for a few good companies to have grasp on some very effective formulae for improve cognitive function and maximize productivity.

Piratall - Nootropic Supplement for Motivation and Energy

Ultimately, finding the right nootropics from scratch can be difficult, but working with an already tested and well-designed supplement is the fast route to successful nootropic use and motivation boosting power!

Some Parting Words of Wisdom…

Changing one’s fortune requires self-motivating, self-promoting, and an incredible amount of focus.  Deriving the right formula to obtain this motivation can be daunting to say the least. But with the right combination of nootropics, it is possible to take a couple pills each day and receive the “pick me up” required to get on about the day and achieve victory!  It is imperative to maintain a healthy and balanced lifestyle as well, as this will give the nootropics the best chance to do their most effective work yet.  Energy and focus nootropics will help with the concentration and initial movement necessary to get started and stay productive. Memory and brain-boosting nootropics will provide the mind a ton of food and lubricated cognitive function. And the right adaptogens will help clear the body of gunk and give all the other nootropics their best chance to shine. All-in-all, it takes a proven, effective stack to produce the best benefits, but if used correctly, nootropics supplements can be the ultimate solution to laziness and motivation!


Brown, R. E. (2016). Hebb and Cattell: The Genesis of the Theory of Fluid and Crystallized Intelligence. Frontiers in Human Neuroscience, 10, 606.

Christiansen, S. and Bhatia, T., (March 21, 2020). What Are Adaptogens? Holistic Health, Very Well Health. Retrieved from:

Entity Health Limited, (2018). History of Bacopa Monnieri. Brain Health. Retrieved from:,treating%20mind-related%20health%20concerns.

Karau, S., and Williams, K., (1993). Social Loafing: A Meta-Analytic Review and Theoretical Integration. Journal of Personality and Social Psychology, Vol. (65)4. Pp. 681-706.

Koshibu K. (2016). Nootropics with potential to (re)build neuroarchitecture. Neural regeneration research, 11(1), 79–80.

Maximets, S., (2019). Determination of Personal and Situation Determinants Laziness. Herald of Kiev Institute of Business and Technology, 42(3), 115-119.

Pase, M., Kean, J., Sarris, J., Neale, C., Scholey, A., and Stough, C., (2012). The Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review of Randomized. The Journal of Alternative and Complementary Medicine, Vol. (18)7. Pp. 1-6. DOI: 10.1089/acm.2011.0367

Roberts, A., (September 21, 2006). Nutraceutical Formulation of a Cognitive Enhancement System. United States Patent Application Publication. Retrieved from:

Ruper and Maxim, (March 13, 2017). Eleutherococcus senticosus. U.S. National Plant Germplasm System.

Schmidt, A., Hammann, F., Wölnerhanssen, B., Meyer-Gerspach, A., Drewe, J., Beglinger, C., and Borgwardt. S., (2014). Green tea extract enhances parieto-frontal connectivity during working memory processing. Psychopharmacology. DOI: 10.1007/s00213-014-3526-1

Sherman, L. (2008). Hawthorn significantly benefits heart failure. The Journal of Chinese Medicine., 87.

Simpson, T., Pase, M., and Stough, C., (August 27, 2015). Bacopa Monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain. Evidence-Based Complementary and Alternative Medicine Vol. (2015).

Stough, C., Downey, L.A., Lloyd, J., Silber, B., Redman, S., Hutchison, C., Wesnes, K. and Nathan, P.J. (2008), Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double‐blind placebo‐controlled randomized trial. Phytother. Res., 22: 1629-1634.

Suliman, N. A., Mat Taib, C. N., Mohd Moklas, M. A., Adenan, M. I., Hidayat Baharuldin, M. T., & Basir, R. (2016). Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic. Evidence-based complementary and alternative medicine : eCAM, 2016, 4391375.

Tassell, M. C., Kingston, R., Gilroy, D., Lehane, M., & Furey, A. (2010). Hawthorn (Crataegus spp.) in the treatment of cardiovascular disease. Pharmacognosy reviews, 4(7), 32–41.

Ying, X., Li, H., Jiang, S., Peng, F., & Lin, Z. (2014). GROUP LAZINESS: THE EFFECT OF SOCIAL LOAFING ON GROUP PERFORMANCE. Social Behavior and Personality, 42(3), 465-471.

Zangara, A., (2003). The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer’s disease. Pharmacology Biochemsitry and Behavior. Vol. (75). Pp. 675-686.

Best Supplements for Entrepreneurs

What Are The Best Supplements for Entrepreneurs?

Are There Supplements for Entrepreneurs?

Entrepreneurs are required to work harder. They work longer hours. In most cases, they have to be more efficient to succeed. It requires grit, persistence, investments, and tenacity. Fortunately, the entrepreneur can gain a bit of an edge by using the right daily supplements. Most of the supplements that are commonly found in an entrepreneur’s stack are considered “nootropics” (Denton, 2017). Most nootropics are natural herbs that provide a positive benefit to the mind or body, with very few negative side effects (Giurgea, 1983) (Gouliaev and Senning, 1994). There are, however, many synthetic drugs and supplements have also been accepted as nootropics (such as the racetams), so long as they enhance mental function or intellectual acuity.

Can Nootropics Be Used Together?

What Nootropics Are Found in Entrepreneur Stacks

Nootropic supplements are very commonly used in various combinations to produce enhanced effects (Blokland and Sambeth, 2016). Some combinations may not be desirable due to cross-tolerance or adverse reactions from taking them at the same time, however, there are many stacks which are effective (Suliman, et al., 2016). There are also many pre-made proprietary formulae which are well-known to work (Angel, 2018). Depending upon the desired effects, it is possible to achieve a variety of benefits from combining some of the best nootropics in the same stack.

What is a Nootropics Stack?

Nootropic stacks, or proprietary formulae as they are called in the commercial industry, are groups of nootropics taken as a daily regimen. Some entrepreneurs create their own stacks, while others prefer to purchase premade proprietary blends which are formulated to produce very specific effects.

Nootropics that Boost the Entrepreneurial Edge

There are many supplements which benefit entrepreneurs. These are some of the most preferred (and most effective) nootropics chosen by top entrepreneurs (in alphabetical order).

*Highlighted nootropics are ingredients in one or more Pirate Botanicals products.

5-HTP (5-hydroxytryptophan) Ingredient Found in Pirate Chill

5-HTP crosses the blood-brain barrier freely and is directly converted into serotonin. It is not limited by biochemical feedback inhibition and is a natural source of amino acids (Hinz, et al., 2012). As a clinically-effective serotonin precursor, it is a well-absorbed, orally-dosed substance with about 70 percent carrying into the bloodstream (Birdsall, 1998). One study notoriously proved that 5-HTP is able to positively influence the brain to improve mood and ultimately efficiency (Shaw, et al., 2002). Another more recent study explained that 5-HTP can positively change “fundamental cognitive operations such as attention” (Weinburg, 2018).

Acetyl L-Carnitine

Acetyl L-Carnitine has been proven to provide neuroprotective benefits to cells, as well as offering antioxidant properties to the body (Wang, et al, 2020)(Karalija, et al., 2012). It is easily absorbed in the stomach, making it an excellent addition to many supplements and is known to reduce fatigue (Swanson, 2018).

Ashwagandha (Withania somnifera)

Ashwagandha has been traditionally used in a variety of cultures for thousands of years. It has a heavy history of use in Ayurvedic medicine. It is a rather popular supplement used by entrepreneurs for its stress-relieving properties. Although many studies involve subjects which are already experiencing stress, these are arguably the best participants for the research. These studies do typically reveal a profound anxiolytic effect on subjects, and suggest that the herb moderates the hypothalamus-pituitary-adrenal axis (Lopresti, et al., 2019). It is also known as Indian Ginseng.

Bacopa Monnieri

Bacopa monnieri is native to many parts of the world and also goes by the common name Indian Pennywort. Although Bacopa is a bit weaker in terms of cognitive influence, it has been proven to have a slight effect on memory (Pase, et al., 2012). Specifically, it helps slightly improve memory recall, though the other cognitive domains have been understudied (2012).


Citicoline is commonly among individuals whom have suffered cognitive impairment (dementia, stroke, Alzheimer’s, etc.) to improve memory loss. Entrepreneurs sometimes include citicoline in their nootropic stack for a small boost to mental energy and learning. Truthfully, however, the studies to support the benefits of citicoline in healthy brains are lacking.


Coluracetam is a member of the racetam family, and it is frequently used to treat Alzheimer’s disease. Although it is typically only used from a reparative/therapeutic perspective in terms of cognition and memory aid, more recent studies are suggesting it may boost cognition for a health brain as well (Malykh and Sadaie, 2010).

GABA (Gamma-Aminobutyric acid)

GABA plays an important role as a neurotransmitter in the central nervous system and reduces neuronal excitability (Olsen, 2006). Sometimes it is used in stress relief and relaxation formulae. It works by binding with GABA receptors and invoking a calming effect in the brain (Westphalen, 2019).

Ginkgo Biloba

Also known as the Maidenhair tree, is only native to China. It is one of the oldest species of plants used as a nootropic, dating back hundreds of millions of years old (Sun, 1998)! It is a very commonly used nutraceuticals offering neuroprotective properties, stress relief, and mild memory enhancement (Mahadevan, 2008).

Ginseng, Siberian (Eleutherococcus senticosus) Ingredient Found in Piratall

Ginseng is one of the most popular nootropics in entrepreneur supplements for its many offerings in terms of cognitive enhancement. Siberian Ginseng is often considered one of the best variants. It is an herbal adaptogen and antioxidant, helping the mind destress and feel clean (Abbai, 2016). It is believed to provide energy, combat fatigue, improve cognitive function, and improve stress response (Cohen, 2019).

Gotu Kola (Centella asiatica)

Gotu Kola is also known as Indian Pennywort. It grows in Asia and has been long revered for its medicinal and culinary uses. Gotu Kola is used in some entrepreneur stacks for its ability to improve blood flow and circulation (Gohil, et al., 2010).

Green Tea Extract Ingredient Found in Piratall

Green Tea extract is a very common constituent in an entrepreneur’s nootropic stack for its many cognitive benefits. It is a powerful adaptogen that is much more effective than most other nootropics at reducing stress (Keiko, 2017). Still, Green Tea extract is able to provide stimulation as it literally contains natural caffeine. The natural caffeine is distributed to the mind and body more evenly than most other caffeine sources. This provides the mind a greater boost to concentration and focus (Godsey, et al., 2020).

Guarana (Paullinia cupana)

Guarana has been hailed among entrepreneurs one of the most effective ingredients in energy drinks and supplements. In recent years, it has been used as a caffeine substitute and antioxidant (Peixoto, 2017). Mostly, it is included in entrepreneur stacks for its light stimulating effects (although it is still no where near as strong as actual caffeine).

Hawthorn (Crataegus) Ingredient Found in Piratall

Hawthorn is a bushy shrub that grows in temperate regions and yields bright red berries. It is well known in traditional Chinese medicine. Hawthorn is a powerful antioxidant and helps reduce stress levels (Strugala, et al., 2016). Both of these prime assets help entrepreneurs better function throughout their busy careers.

Huperzine A Ingredient Found in Piratall

Huperzine A is an alkaloid compound that is extracted from the Chinese firmoss Huperzia serrata. It is also a big part of traditional Chinese medicine. It has a tremendous history fighting cognitive impairments, Alzheimer’s, and is considered an anti-dementia aid (Yue, et al., 2012). Huperzine A is one of the most popular nootropics in entrepreneur stacks for its favorable impact to cognitive function (Wessinger, 2018).

L-Theanine Ingredient Found in Pirate Chill

L-Theanine is an amino acid analogue and is a special constituent isolated from gyokuro leaves. It is capable of enhancing mental sharpness in the same way as meditation (Challem, 2007). It is frequently used to promote peace and calmness (2007). It is found in many entrepreneur stacks for its stress relieving properties and ability to promote focus.

Lemon Balm (Melissa officinalis)

Lemon Balm is sometimes used in entrepreneur nootropic stacks to reduce stress and induce sleep (Cronkleton, 2019). In fact, it has even been proven to be effective when it is contained in food (Scholey, et al., 2014).

Lion’s Mane Mushroom (Hericium erinaceus)

Lion’s Mane Mushroom goes by many names including “Monkey Head Mushroom,” “Bearded Tooth Mushroom,” and even the “Hedgehog Mushroom.” It is found growing on American Beech trees in the late summer to early fall. Frequently, it is found in nootropic stacks for its mild cognitive improvement and mood regulation benefits (Wiley, 2019).

Modafinil (Provigil and Nuvigil)

Many brand names for Modafinil exist, probably most famous of the bunch being “Provigil.” It is frequently hailed as a cognitive enhancer, but very little research suggests any efficacy in terms of cognitive improvement. It is still used to help treat sleepiness and is listed as a scheduled substance in the United States.

Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester)

Although Noopept is not FDA approved, it is sometimes used by entrepreneurs for its purported neuroprotective and neuroregenerative properties. Truthfully, however, it has mostly only been studied in efficacy among people with traumatic brain injuries (Zainullina, 2019).

Passion Flower (Passiflora) Ingredient Found in Pirate Chill

Passion Flower (sometimes spelled Passionflower) are beautiful purple flowers which grow on vines that may come in the form of trees or shrubs. It has been used in traditional medicines for generations. Typically it is used for its sedative properties, for mild pain relief, and to reduce anxiety (NCCIH, 2016). It is a very common nootropic for entrepreneurs who need to relieve tension.


Phenibut is commonly used to reduce anxiety and improve sleep. Tolerance to phenibut builds rather quickly. And although it is an effective nootropics, side effects can be a little exhaustive, making it a less common choice for an entrepreneur stack (Lapin, 2001).


Although Piracetam is most commonly used to treat CNS disorders, it is found in a variety of nootropic stacks. Recent studies have revealed Piracetam is a somewhat promising candidate for being a neuroprotective and neuroregenerative nootropic (Malykh, 2010).

Rhodiola rosea Ingredient Found in Pirate Blast

Rhodiola is native to wild Artic climates and is a large part of many traditional medicines. It is known to reduce stress levels, decrease fatigue, and promote energy (Ishaque, 2010). It is a common constituent in energy and anti-fatique-based nootropic stacks (Zhang, 2009). It is frequently used by entrepreneurs to improve their overall alertness and focus.


Taurine is commonly found in energy drinks. It is extracted from animal tissue, such as its original biosynthesis from ox bile (Tiedemann and Gmelin, 1827). It is also an antioxidant, helping the body to rid itself of cell-damaging free radicals (Xu, et al., 2008).


Tyrosine is one of the body’s standard non-essential amino acids used to synthesize proteins. Although it is rather weak in terms of noticeable effects, it is a neurotransmitter precursor that stimulates the production of dopamine and norepinephrine (Rasmussen, 1983).

Valarian Root Ingredient Found in Pirate Chill

Valarian (Valeriana officinalis) is a sweet smelling plant that is native to Europe and Asia. Two primary alkaloids of interest, valerianine and valerine work by binding to the brain’s GABA receptors. Valarian is used in nootropic supplements for its calming, sedative, and peaceful effects (James, 2003).


Vinpocetine is a synthetic derivative, ultimately created from Vincamine extracted from Voacanga africana seeds. It is typically used to treat post-stroke victims, and people suffering from various forms of dementia (Liu, et al., 2019)(Zhang, 2018). While it has been proven that it does provide some cognitive benefits to those who already suffer cognitive impairments of some kind, there are very few studies which support these same cognitive benefits for healthy individuals.

Yerba Mate

Yerba Mate is native to South America and is traditionally brewed into a beverage. It is very commonly ingested to improve metabolic health and overall mood (Alkhatib and Atcheson, 2017). A more relaxed state of mind can help an entrepreneur maintain focus, work longer, and achieve more. Containing a small amount of caffeine, it is perhaps one of the best ways to ingest caffeine for its positive benefits, with none of the negatives side effects (Ghezelbash, 2020).

Yohimbe Ingredient Found in Pirate Blast

Yohimbe comes from the bark of one of two trees located in Africa or South America only. Yohimbe is very frequently used for its ability to increase blood flow. It is used to decrease impotence, improve athletic performance, enhance weight loss efforts, and so much more (NIH, 2016). Yohimbine, the primary constituent alkaloid in Yohimbe, is known to induce noradrenergic stimulation which enhances memory consolidation (Wingenfeld, et al., 2013).

A Few Words About Caffeine, Aniracetam, and Others

Caffeine is often considered to be a nootropic. The definition of nootropic literally states that there are no negative side effects to using nootropics, but many people experience adverse reactions from using caffeine (Temple, et al., 2017). While there are some positive benefits from using caffeine for most people, some people experience cardiovascular function impairments, sleep deprivation, and other problems (2017). Still, many sites will claim caffeine as a nootropic, erroneously. And despite the benefits many people receive from caffeine intake, it will never be a true nootropic.

Aniracetam was long thought to improve cognitive function and memory in human beings. It has also been credited for improving learning as well. The studies which have backed up the idea that aniracetam improves learning, are on subjects which have a cognitive impairment. Many recent studies have painted a different picture, investigating the effects of aniracetam on healthy minds instead. These studies have revealed the substance to have no positive effect on learning, memory, or cognitive function (Reynolds, 2018) (Phillips, 2019).

Using Nootropic Supplements Effectively

Effective Nootropic Supplements for Entrepreneurs

Entrepreneurs put in so many hours and so much work that it makes the most sense to maximize efficiency within reasonable means. The top combinations of nootropic stacks are one of the best ways to make the most use of time as an entrepreneur (Denton, 2017). Whether the stack is devised to create energy or enhance focus, or to improve fluid intelligence, having a daily regimen most certainly gives the entrepreneur a significant advantage (Suliman, et al., 2016). And with the wide variety of information available, it has become easier than ever for any entrepreneur to select the proprietary blend that works best for them!


Abbai, R., Mathiyalagan, R., Markus, J., Yeon-Ju, K., Wang, C., Singh, P., . . . Yang, D. C. (2016). Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng. International Journal of Nanomedicine, 11, 3131-3143. doi:

Alkhatib, A., & Atcheson, R. (2017). Yerba Maté (Ilex paraguariensis) Metabolic, Satiety, and Mood State Effects at Rest and during Prolonged Exercise. Nutrients, 9(8), 882.

Angel, B., (October 30, 2018). Unstoppable: A 90-Day Plan to Biohack Your Mind and Body for Success. Entrepreneur Press. ASIN: B07GJSNTH9. Pp. 89-92.

Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998;3(4):271-280.

Blokland, A., and Sambeth, A., (2016). The Effects of a Combination of Nootropic Ingredients on Cognition in Healthy Young Volunteers. Retrieved from:

Cohen, J., (December 15, 2019). 12 Health Benefits of Ginseng. Self Hacked. Retrieved from:

Cronkleton, E., (March 7, 2019). 10 Benefits of Lemon Balm and How to Use It. Healthline. Retrieved from:

Denton, M., (2017). Every Entrepreneur Needs Flow. Nootropics Can Get You There. Retrieved from:

Ghezelbash, P., (2020). Yerba Mate as a Nootropic: A Simple, Science-Based Review. Nootropics Resources. Retrieved from:

Giurgea CE, Greindl MG, Preat S. Nootropic drugs and aging. Acta Psychiatr Belg. 1983;83(4):349-358.

Godsey, C., Horowitz, D., and Sather, R., (2020). Green Tea Extract University of Rochester Medical Center. Rochester, NY. Retreived from:

Gohil, K. J., Patel, J. A., & Gajjar, A. K. (2010). Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all. Indian journal of pharmaceutical sciences, 72(5), 546–556.

Gouliaev AH Senning A Piracetam and other structurally related nootropics. Brain Res Rev. 1994; 19: 180-222.

Hinz, M., Stein, A., & Uncini, T. (2012). 5-HTP efficacy and contraindications. Neuropsychiatric disease and treatment, 8, 323–328.

Ishaque, S., Shamseer, L., Bukutu, C., (2012). Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complement Altern Med 12, 70.

James, S. (2003). Herbal and OTC Sleep Remedies: Implications for Psychiatry. The Psychiatric Times., 20(12).

Karalija, A., Novikova, L., Kingham, P., Wiberg, M., and Novikov, L., (2012). Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats. PLoS ONE. ISSN: 1932-6203. Retrieved from:

Keiko Unnoa, b, Hiroshi Yamadac, & Kazuaki Iguchia. (2017). Anti-stress Effect of Green Tea with Lowered Caffeine on Humans : A Pilot Study. Biological & Pharmaceutical Bulletin., 40(6), 902–909.

Lapin I. (2001). Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug. CNS drug reviews, 7(4), 471–481.

Liu, Y., Yin, Y., Lu, Q., Dan, Y., Xu, M., Song, G., & Li, C. (2019). Vinpocetine in the treatment of poststroke cognitive dysfunction. Medicine., 98(6).

Lopresti, A., Smith, S., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. Medicine., 98(37).

Mahadevan, S. and Park, Y. (2008), Multifaceted Therapeutic Benefits of Ginkgo biloba L.: Chemistry, Efficacy, Safety, and Uses. Journal of Food Science, 73: R14-R19. doi:10.1111/j.1750-3841.2007.00597.x

Malykh, A. G., & Sadaie, M. R. (2010). Piracetam and piracetam-like drugs: From basic science to novel clinical applications to CNS disorders. Drugs, 70(3), 287-312. doi:

NCCIH (September 2016). Passionflower. National Center for Complementary and Integrative Health. Retreived from:

NIH (September, 2016). Yohimbe. National Center for Complementary and Integrative Health. Retrieved from:

Olsen R., and Betz, H. (2006). GABA and Glycine. Basic Neurochemistry: Molecular, Cellular and Medical Aspects (7th ed.). Elsevier. pp. 291–302.

Pase M., Kean J., Sarris J., Neale, C., Scholey A., Stough C., (2012). The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. 2012;18:647–652.

Peixoto, H., Roxo, M., Röhrig, T., Richling, E., Wang, X., & Wink, M. (2017). Anti-Aging and Antioxidant Potential of Paullinia cupana var. sorbilis: Findings in Caenorhabditis elegans Indicate a New Utilization for Roasted Seeds of Guarana. Medicines (Basel, Switzerland), 4(3), 61.

Phillips, H., McDowell, A., Mielby, B., Tucker, I., and Colombo, M., (April 19, 2019). Aniracetam does not improve working memory in neurologically healthy pigeons. PLoS One. Retrieved from:

Rasmussen, D., Ishizuka, B., Quigley, M., Yen, S., (1983). Effects of Tyrosine and Tryptophan Ingestion on Plasma Catecholamine and 3,4-Dihydroxyphenylacetic Acid Concentrations. The Journal of Clinical Endocrinology & Metabolism. Vol (57). Iss (4). Pp. 760–763.

Reynolds CD, Jefferson TS, Volquardsen M et al. Oral aniracetam treatment in C57BL/6J mice without pre-existing cognitive dysfunction reveals no changes in learning, memory, anxiety or stereotypy [version 3; peer review: 2 approved, 1 approved with reservations]. F1000Research 2018, 6:1452 (

Scholey, A., Gibbs, A., Neale, C., Perry, N., Ossoukhova, A., Bilog, V., . . . Buchwald-Werner, S. (2014). Anti-stress effects of lemon balm-containing foods. Nutrients, 6(11), 4805-4821. doi:

Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev. 2002;(1):CD003198. doi:10.1002/14651858.CD003198

Strugała, P., Gładkowski, W., Kucharska, A.Z., Sokół‐Łętowska, A. and Gabrielska, J. (2016), Antioxidant activity and anti‐inflammatory effect of fruit extracts from blackcurrant, chokeberry, hawthorn, and rosehip, and their mixture with linseed oil on a model lipid membrane. Eur. J. Lipid Sci. Technol., 118: 461-474. doi:10.1002/ejlt.201500001

Suliman, N. A., Mat Taib, C. N., Mohd Moklas, M. A., Adenan, M. I., Hidayat Baharuldin, M. T., & Basir, R. (2016). Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic. Evidence-based complementary and alternative medicine : eCAM, 2016, 4391375.

Sun, W. 1998. Ginkgo biloba. The IUCN Red List of Threatened Species 1998: e.T32353A9700472. Downloaded on 17 July 2020.

Swonson, J., (2018). Acetyl-L-carnitine: Can it relieve MS fatigue? Mayo Clinic. Retrieved from:

Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017). The Safety of Ingested Caffeine: A Comprehensive Review. Frontiers in psychiatry, 8, 80.

Tiedemann, F. and Gmelin, L. (1827), Einige neue Bestandtheile der Galle des Ochsen. Ann. Phys., 85: 326-337. doi:10.1002/andp.18270850214

Wang, S., Xu, J., Zheng, J., Zhang, X., Shao, J., Zhao, L., & Hao, J. (2020). Anti-Inflammatory and Antioxidant Effects of Acetyl-L-Carnitine on Atherosclerotic Rats. Medical science monitor : international medical journal of experimental and clinical research, 26, e920250.

Weinberg-Wolf, H., Fagan, N.A., Anderson, G.M. et al. The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque. Neuropsychopharmacol 43, 1589–1598 (2018).

Wessinger, C., (2018). Effect of Huperzine A on Cognitive Function and Perception of Effort During Exercise U.S. National Library of Medicine. Retrieved from:

Westphalen, D., (2019). What Does Gamma Aminobutyric Acid (GABA) Do? Healthline. Retrieved from:

Wiley, M., (January 29, 2019). 5 Brain Boosting Benefits of Lions Mane Mushroom. Botanical Health. Retrieved from:

Wingenfeld K, Kuffel A, Uhlmann C, et al. Effects of noradrenergic stimulation on memory in patients with major depressive disorder. Stress. 2013;16(2):191-201. doi:10.3109/10253890.2012.708951

Xu, Y. J., Arneja, A. S., Tappia, P. S., & Dhalla, N. S. (2008). The potential health benefits of taurine in cardiovascular disease. Experimental and clinical cardiology, 13(2), 57–65.

Yue, J., Dong, B. R., Lin, X., Yang, M., Wu, H. M., & Wu, T. (2012). Huperzine A for mild cognitive impairment. The Cochrane database of systematic reviews, 12(12), CD008827.

Zainullina, L.F., Ivanova, T.V., Ostrovskaya, R.U. et al. Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation. Bull Exp Biol Med 166, 466–468 (2019).

Zhang, Y., Li, J., and Yan, C., (January 15, 2018). An update on vinpocetine: New discoveries and clinical implications. European Journal of Pharmacology. Vol. (819). Pp. 30-34.

Zhang ZJ; Tong Y; Zou J; Chen PJ; Yu DH, (2009). Chinese journal of integrative medicine.Vol. 15 (3), pp. 177-83; Publisher: Chinese Journal of Integrated Traditional and Western Medicine Press ; PMID: 19568709;

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